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Microsleep versus Sleep Onset Latency during Maintenance Wakefulness Tests: Which One Is the Best Marker of Sleepiness?

The interpretation of the Maintenance Wakefulness Test (MWT) relies on sleep onset detection. However, microsleeps (MSs), i.e., brief periods of sleep intrusion during wakefulness, may occur before sleep onset. We assessed the prevalence of MSs during the MWT and their contribution to the diagnosis...

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Autores principales: Des Champs de Boishebert, Ludivine, Pradat, Pierre, Bastuji, Hélène, Ricordeau, François, Gormand, Frédéric, Le Cam, Pierre, Stauffer, Emeric, Petitjean, Thierry, Peter-Derex, Laure
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161762/
https://www.ncbi.nlm.nih.gov/pubmed/33946265
http://dx.doi.org/10.3390/clockssleep3020016
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author Des Champs de Boishebert, Ludivine
Pradat, Pierre
Bastuji, Hélène
Ricordeau, François
Gormand, Frédéric
Le Cam, Pierre
Stauffer, Emeric
Petitjean, Thierry
Peter-Derex, Laure
author_facet Des Champs de Boishebert, Ludivine
Pradat, Pierre
Bastuji, Hélène
Ricordeau, François
Gormand, Frédéric
Le Cam, Pierre
Stauffer, Emeric
Petitjean, Thierry
Peter-Derex, Laure
author_sort Des Champs de Boishebert, Ludivine
collection PubMed
description The interpretation of the Maintenance Wakefulness Test (MWT) relies on sleep onset detection. However, microsleeps (MSs), i.e., brief periods of sleep intrusion during wakefulness, may occur before sleep onset. We assessed the prevalence of MSs during the MWT and their contribution to the diagnosis of residual sleepiness in patients treated for obstructive sleep apnea (OSA) or hypersomnia. The MWT of 98 patients (89 OSA, 82.6% male) were analyzed for MS scoring. Polysomnography parameters and clinical data were collected. The diagnostic value for detecting sleepiness (Epworth Sleepiness Scale > 10) of sleep onset latency (SOL) and of the first MS latency (MSL) was assessed by the area under the receiver operating characteristic (ROC) curve (AUC, 95% CI). At least one MS was observed in 62.2% of patients. MSL was positively correlated with SOL (r = 0.72, p < 0.0001) but not with subjective scales, clinical variables, or polysomnography parameters. The use of SOL or MSL did not influence the diagnostic performance of the MWT for subjective sleepiness assessment (AUC = 0.66 95% CI (0.56, 0.77) versus 0.63 95% CI (0.51, 0.74)). MSs are frequent during MWTs performed in patients treated for sleep disorders, even in the absence of subjective sleepiness, and may represent physiological markers of the wake-to-sleep transition.
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spelling pubmed-81617622021-05-29 Microsleep versus Sleep Onset Latency during Maintenance Wakefulness Tests: Which One Is the Best Marker of Sleepiness? Des Champs de Boishebert, Ludivine Pradat, Pierre Bastuji, Hélène Ricordeau, François Gormand, Frédéric Le Cam, Pierre Stauffer, Emeric Petitjean, Thierry Peter-Derex, Laure Clocks Sleep Article The interpretation of the Maintenance Wakefulness Test (MWT) relies on sleep onset detection. However, microsleeps (MSs), i.e., brief periods of sleep intrusion during wakefulness, may occur before sleep onset. We assessed the prevalence of MSs during the MWT and their contribution to the diagnosis of residual sleepiness in patients treated for obstructive sleep apnea (OSA) or hypersomnia. The MWT of 98 patients (89 OSA, 82.6% male) were analyzed for MS scoring. Polysomnography parameters and clinical data were collected. The diagnostic value for detecting sleepiness (Epworth Sleepiness Scale > 10) of sleep onset latency (SOL) and of the first MS latency (MSL) was assessed by the area under the receiver operating characteristic (ROC) curve (AUC, 95% CI). At least one MS was observed in 62.2% of patients. MSL was positively correlated with SOL (r = 0.72, p < 0.0001) but not with subjective scales, clinical variables, or polysomnography parameters. The use of SOL or MSL did not influence the diagnostic performance of the MWT for subjective sleepiness assessment (AUC = 0.66 95% CI (0.56, 0.77) versus 0.63 95% CI (0.51, 0.74)). MSs are frequent during MWTs performed in patients treated for sleep disorders, even in the absence of subjective sleepiness, and may represent physiological markers of the wake-to-sleep transition. MDPI 2021-04-30 /pmc/articles/PMC8161762/ /pubmed/33946265 http://dx.doi.org/10.3390/clockssleep3020016 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Des Champs de Boishebert, Ludivine
Pradat, Pierre
Bastuji, Hélène
Ricordeau, François
Gormand, Frédéric
Le Cam, Pierre
Stauffer, Emeric
Petitjean, Thierry
Peter-Derex, Laure
Microsleep versus Sleep Onset Latency during Maintenance Wakefulness Tests: Which One Is the Best Marker of Sleepiness?
title Microsleep versus Sleep Onset Latency during Maintenance Wakefulness Tests: Which One Is the Best Marker of Sleepiness?
title_full Microsleep versus Sleep Onset Latency during Maintenance Wakefulness Tests: Which One Is the Best Marker of Sleepiness?
title_fullStr Microsleep versus Sleep Onset Latency during Maintenance Wakefulness Tests: Which One Is the Best Marker of Sleepiness?
title_full_unstemmed Microsleep versus Sleep Onset Latency during Maintenance Wakefulness Tests: Which One Is the Best Marker of Sleepiness?
title_short Microsleep versus Sleep Onset Latency during Maintenance Wakefulness Tests: Which One Is the Best Marker of Sleepiness?
title_sort microsleep versus sleep onset latency during maintenance wakefulness tests: which one is the best marker of sleepiness?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161762/
https://www.ncbi.nlm.nih.gov/pubmed/33946265
http://dx.doi.org/10.3390/clockssleep3020016
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