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Significance of Concurrent Chemoradiotherapy as Primary Treatment in Patients with Metastatic Cervical Cancer

(1) This study investigated the prognostic impact of tumor size in patients with metastatic cervical cancer. (2) Methods: Seventy-three cervical cancer patients in our institute were stratified into two groups based on distant metastasis: para-aortic lymph node metastasis alone (IIIC2) or spread to...

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Autores principales: Hattori, Satomi, Yoshikawa, Nobuhisa, Mogi, Kazumasa, Yoshida, Kosuke, Yoshihara, Masato, Tamauchi, Satoshi, Ikeda, Yoshiki, Yokoi, Akira, Nishino, Kimihiro, Niimi, Kaoru, Suzuki, Shiro, Kajiyama, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161771/
https://www.ncbi.nlm.nih.gov/pubmed/33946737
http://dx.doi.org/10.3390/curroncol28030155
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author Hattori, Satomi
Yoshikawa, Nobuhisa
Mogi, Kazumasa
Yoshida, Kosuke
Yoshihara, Masato
Tamauchi, Satoshi
Ikeda, Yoshiki
Yokoi, Akira
Nishino, Kimihiro
Niimi, Kaoru
Suzuki, Shiro
Kajiyama, Hiroaki
author_facet Hattori, Satomi
Yoshikawa, Nobuhisa
Mogi, Kazumasa
Yoshida, Kosuke
Yoshihara, Masato
Tamauchi, Satoshi
Ikeda, Yoshiki
Yokoi, Akira
Nishino, Kimihiro
Niimi, Kaoru
Suzuki, Shiro
Kajiyama, Hiroaki
author_sort Hattori, Satomi
collection PubMed
description (1) This study investigated the prognostic impact of tumor size in patients with metastatic cervical cancer. (2) Methods: Seventy-three cervical cancer patients in our institute were stratified into two groups based on distant metastasis: para-aortic lymph node metastasis alone (IIIC2) or spread to distant visceral organs with or without para-aortic lymph node metastasis (IVB) to identify primary tumor size and concurrent chemoradiotherapy. (3) Results: The overall survival (OS) for patients with a tumor >6.9 cm in size was significantly poorer than that for patients with a tumor ≤6.9 cm in the IVB group (p = 0.0028); the corresponding five-year OS rates in patients with a tumor ≤6.9 and >6.9 cm were 53.3% and 13.4%, respectively. In the multivariate analysis, tumor size and primary treatment were significantly associated with survival in metastatic cervical cancer. (4) Conclusions: Tumor size ≤6.9 cm and concurrent chemoradiotherapy as the primary treatment were favorable prognostic factors for patients with metastatic cervical cancer.
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spelling pubmed-81617712021-05-29 Significance of Concurrent Chemoradiotherapy as Primary Treatment in Patients with Metastatic Cervical Cancer Hattori, Satomi Yoshikawa, Nobuhisa Mogi, Kazumasa Yoshida, Kosuke Yoshihara, Masato Tamauchi, Satoshi Ikeda, Yoshiki Yokoi, Akira Nishino, Kimihiro Niimi, Kaoru Suzuki, Shiro Kajiyama, Hiroaki Curr Oncol Article (1) This study investigated the prognostic impact of tumor size in patients with metastatic cervical cancer. (2) Methods: Seventy-three cervical cancer patients in our institute were stratified into two groups based on distant metastasis: para-aortic lymph node metastasis alone (IIIC2) or spread to distant visceral organs with or without para-aortic lymph node metastasis (IVB) to identify primary tumor size and concurrent chemoradiotherapy. (3) Results: The overall survival (OS) for patients with a tumor >6.9 cm in size was significantly poorer than that for patients with a tumor ≤6.9 cm in the IVB group (p = 0.0028); the corresponding five-year OS rates in patients with a tumor ≤6.9 and >6.9 cm were 53.3% and 13.4%, respectively. In the multivariate analysis, tumor size and primary treatment were significantly associated with survival in metastatic cervical cancer. (4) Conclusions: Tumor size ≤6.9 cm and concurrent chemoradiotherapy as the primary treatment were favorable prognostic factors for patients with metastatic cervical cancer. MDPI 2021-04-29 /pmc/articles/PMC8161771/ /pubmed/33946737 http://dx.doi.org/10.3390/curroncol28030155 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hattori, Satomi
Yoshikawa, Nobuhisa
Mogi, Kazumasa
Yoshida, Kosuke
Yoshihara, Masato
Tamauchi, Satoshi
Ikeda, Yoshiki
Yokoi, Akira
Nishino, Kimihiro
Niimi, Kaoru
Suzuki, Shiro
Kajiyama, Hiroaki
Significance of Concurrent Chemoradiotherapy as Primary Treatment in Patients with Metastatic Cervical Cancer
title Significance of Concurrent Chemoradiotherapy as Primary Treatment in Patients with Metastatic Cervical Cancer
title_full Significance of Concurrent Chemoradiotherapy as Primary Treatment in Patients with Metastatic Cervical Cancer
title_fullStr Significance of Concurrent Chemoradiotherapy as Primary Treatment in Patients with Metastatic Cervical Cancer
title_full_unstemmed Significance of Concurrent Chemoradiotherapy as Primary Treatment in Patients with Metastatic Cervical Cancer
title_short Significance of Concurrent Chemoradiotherapy as Primary Treatment in Patients with Metastatic Cervical Cancer
title_sort significance of concurrent chemoradiotherapy as primary treatment in patients with metastatic cervical cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161771/
https://www.ncbi.nlm.nih.gov/pubmed/33946737
http://dx.doi.org/10.3390/curroncol28030155
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