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Outcomes of Older Patients with Resectable Colorectal Liver Metastases Cancer (CRLM): Single Center Experience
Surgery is the only potential curative option of CRLM if resectable. The curative approach in patients over 70 years old is challenging mainly because of comorbidities and other geriatric syndromes. Herein, we report outcomes of older patients with resectable CRLM in our center. We retrospectively a...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161835/ https://www.ncbi.nlm.nih.gov/pubmed/34069871 http://dx.doi.org/10.3390/curroncol28030176 |
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author | Nassabein, Rami Mansour, Laura Richard, Corentin Vandenbroucke-Menu, Franck Aubin, Francine Ayoub, Jean-Pierre Dagenais, Michel Lapointe, Real Letourneau, Richard Plasse, Marylène Roy, André Turcotte, Simon Tehfe, Mustapha |
author_facet | Nassabein, Rami Mansour, Laura Richard, Corentin Vandenbroucke-Menu, Franck Aubin, Francine Ayoub, Jean-Pierre Dagenais, Michel Lapointe, Real Letourneau, Richard Plasse, Marylène Roy, André Turcotte, Simon Tehfe, Mustapha |
author_sort | Nassabein, Rami |
collection | PubMed |
description | Surgery is the only potential curative option of CRLM if resectable. The curative approach in patients over 70 years old is challenging mainly because of comorbidities and other geriatric syndromes. Herein, we report outcomes of older patients with resectable CRLM in our center. We retrospectively analyzed characteristics and outcomes of older patients with CRLM operated at “Centre Hospitalier de l’Université de Montréal” (CHUM) between 2010 and 2019. We identified 210 patients aged ≥70 years with a median age of 76 (range: 70–85). CRLM were synchronous in 56% of patients. Median disease-free survival (DFS) was 41.3 months. Median overall survival (OS) was 62.2 months and estimated 5-year survival rate was 51.5% similar to those of younger counterparts. Patients with metachronous CRLM had a trend to a higher OS compared to those with synchronous disease (67.2 vs. 58.7 months; p = 0.42). Factors associated with lower survival in the multivariate analysis were right-sided tumors and increased Charlson Comorbidity index (CCI). Survival outcomes of patients aged ≥70 years were comparable to those of younger patients and those reported in the literature. Age should not be a limiting factor in the curative management of older patients with resectable CRLM. |
format | Online Article Text |
id | pubmed-8161835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81618352021-05-29 Outcomes of Older Patients with Resectable Colorectal Liver Metastases Cancer (CRLM): Single Center Experience Nassabein, Rami Mansour, Laura Richard, Corentin Vandenbroucke-Menu, Franck Aubin, Francine Ayoub, Jean-Pierre Dagenais, Michel Lapointe, Real Letourneau, Richard Plasse, Marylène Roy, André Turcotte, Simon Tehfe, Mustapha Curr Oncol Article Surgery is the only potential curative option of CRLM if resectable. The curative approach in patients over 70 years old is challenging mainly because of comorbidities and other geriatric syndromes. Herein, we report outcomes of older patients with resectable CRLM in our center. We retrospectively analyzed characteristics and outcomes of older patients with CRLM operated at “Centre Hospitalier de l’Université de Montréal” (CHUM) between 2010 and 2019. We identified 210 patients aged ≥70 years with a median age of 76 (range: 70–85). CRLM were synchronous in 56% of patients. Median disease-free survival (DFS) was 41.3 months. Median overall survival (OS) was 62.2 months and estimated 5-year survival rate was 51.5% similar to those of younger counterparts. Patients with metachronous CRLM had a trend to a higher OS compared to those with synchronous disease (67.2 vs. 58.7 months; p = 0.42). Factors associated with lower survival in the multivariate analysis were right-sided tumors and increased Charlson Comorbidity index (CCI). Survival outcomes of patients aged ≥70 years were comparable to those of younger patients and those reported in the literature. Age should not be a limiting factor in the curative management of older patients with resectable CRLM. MDPI 2021-05-18 /pmc/articles/PMC8161835/ /pubmed/34069871 http://dx.doi.org/10.3390/curroncol28030176 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nassabein, Rami Mansour, Laura Richard, Corentin Vandenbroucke-Menu, Franck Aubin, Francine Ayoub, Jean-Pierre Dagenais, Michel Lapointe, Real Letourneau, Richard Plasse, Marylène Roy, André Turcotte, Simon Tehfe, Mustapha Outcomes of Older Patients with Resectable Colorectal Liver Metastases Cancer (CRLM): Single Center Experience |
title | Outcomes of Older Patients with Resectable Colorectal Liver Metastases Cancer (CRLM): Single Center Experience |
title_full | Outcomes of Older Patients with Resectable Colorectal Liver Metastases Cancer (CRLM): Single Center Experience |
title_fullStr | Outcomes of Older Patients with Resectable Colorectal Liver Metastases Cancer (CRLM): Single Center Experience |
title_full_unstemmed | Outcomes of Older Patients with Resectable Colorectal Liver Metastases Cancer (CRLM): Single Center Experience |
title_short | Outcomes of Older Patients with Resectable Colorectal Liver Metastases Cancer (CRLM): Single Center Experience |
title_sort | outcomes of older patients with resectable colorectal liver metastases cancer (crlm): single center experience |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161835/ https://www.ncbi.nlm.nih.gov/pubmed/34069871 http://dx.doi.org/10.3390/curroncol28030176 |
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