The emerging role of RNA N6-methyladenosine methylation in breast cancer

N6-methyladenosine (m6A) modification is the most prevalent internal mRNA modification and is involved in many biological processes in eukaryotes. Accumulating evidence has demonstrated that m6A may play either a promoting or suppressing role in breast cancer, including in tumorigenesis, metastasis...

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Detalles Bibliográficos
Autores principales: Zheng, Fangchao, Du, Feng, Zhao, Jiuda, Wang, Xue, Si, Yiran, Jin, Peng, Qian, Haili, Xu, Binghe, Yuan, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161983/
https://www.ncbi.nlm.nih.gov/pubmed/34044876
http://dx.doi.org/10.1186/s40364-021-00295-8
Descripción
Sumario:N6-methyladenosine (m6A) modification is the most prevalent internal mRNA modification and is involved in many biological processes in eukaryotes. Accumulating evidence has demonstrated that m6A may play either a promoting or suppressing role in breast cancer, including in tumorigenesis, metastasis and angiogenesis. In this review, we summarize the latest research progress on the biological function and prognostic value of m6A modification in breast cancer, as well as potential related therapeutic strategies.

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