The emerging role of RNA N6-methyladenosine methylation in breast cancer

N6-methyladenosine (m6A) modification is the most prevalent internal mRNA modification and is involved in many biological processes in eukaryotes. Accumulating evidence has demonstrated that m6A may play either a promoting or suppressing role in breast cancer, including in tumorigenesis, metastasis...

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Autores principales: Zheng, Fangchao, Du, Feng, Zhao, Jiuda, Wang, Xue, Si, Yiran, Jin, Peng, Qian, Haili, Xu, Binghe, Yuan, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161983/
https://www.ncbi.nlm.nih.gov/pubmed/34044876
http://dx.doi.org/10.1186/s40364-021-00295-8
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author Zheng, Fangchao
Du, Feng
Zhao, Jiuda
Wang, Xue
Si, Yiran
Jin, Peng
Qian, Haili
Xu, Binghe
Yuan, Peng
author_facet Zheng, Fangchao
Du, Feng
Zhao, Jiuda
Wang, Xue
Si, Yiran
Jin, Peng
Qian, Haili
Xu, Binghe
Yuan, Peng
author_sort Zheng, Fangchao
collection PubMed
description N6-methyladenosine (m6A) modification is the most prevalent internal mRNA modification and is involved in many biological processes in eukaryotes. Accumulating evidence has demonstrated that m6A may play either a promoting or suppressing role in breast cancer, including in tumorigenesis, metastasis and angiogenesis. In this review, we summarize the latest research progress on the biological function and prognostic value of m6A modification in breast cancer, as well as potential related therapeutic strategies.
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spelling pubmed-81619832021-06-01 The emerging role of RNA N6-methyladenosine methylation in breast cancer Zheng, Fangchao Du, Feng Zhao, Jiuda Wang, Xue Si, Yiran Jin, Peng Qian, Haili Xu, Binghe Yuan, Peng Biomark Res Review N6-methyladenosine (m6A) modification is the most prevalent internal mRNA modification and is involved in many biological processes in eukaryotes. Accumulating evidence has demonstrated that m6A may play either a promoting or suppressing role in breast cancer, including in tumorigenesis, metastasis and angiogenesis. In this review, we summarize the latest research progress on the biological function and prognostic value of m6A modification in breast cancer, as well as potential related therapeutic strategies. BioMed Central 2021-05-27 /pmc/articles/PMC8161983/ /pubmed/34044876 http://dx.doi.org/10.1186/s40364-021-00295-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zheng, Fangchao
Du, Feng
Zhao, Jiuda
Wang, Xue
Si, Yiran
Jin, Peng
Qian, Haili
Xu, Binghe
Yuan, Peng
The emerging role of RNA N6-methyladenosine methylation in breast cancer
title The emerging role of RNA N6-methyladenosine methylation in breast cancer
title_full The emerging role of RNA N6-methyladenosine methylation in breast cancer
title_fullStr The emerging role of RNA N6-methyladenosine methylation in breast cancer
title_full_unstemmed The emerging role of RNA N6-methyladenosine methylation in breast cancer
title_short The emerging role of RNA N6-methyladenosine methylation in breast cancer
title_sort emerging role of rna n6-methyladenosine methylation in breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161983/
https://www.ncbi.nlm.nih.gov/pubmed/34044876
http://dx.doi.org/10.1186/s40364-021-00295-8
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