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Exploring modular reengineering strategies to redesign the teicoplanin non-ribosomal peptide synthetase

Non-ribosomal peptide synthesis is an important biosynthesis pathway in secondary metabolism. In this study we have investigated modularisation and redesign strategies for the glycopeptide antibiotic teicoplanin. Using the relocation or exchange of domains within the NRPS modules, we have identified...

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Detalles Bibliográficos
Autores principales:	Kaniusaite, Milda, Goode, Robert J. A., Tailhades, Julien, Schittenhelm, Ralf B., Cryle, Max J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162109/ https://www.ncbi.nlm.nih.gov/pubmed/34094211 http://dx.doi.org/10.1039/d0sc03483e

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