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Assessing the performance of rotational spectroscopy in chiral analysis
The capabilities of rotational spectroscopy-based methods as tools to deliver accurate and precise chirality-sensitive information are still breaking ground, but their applicability in the challenging field of analytical chemistry is already clear. In this mini review, we explore the current abiliti...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162261/ https://www.ncbi.nlm.nih.gov/pubmed/34123188 http://dx.doi.org/10.1039/d0sc03752d |
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author | Domingos, Sérgio R. Pérez, Cristóbal Marshall, Mark D. Leung, Helen O. Schnell, Melanie |
author_facet | Domingos, Sérgio R. Pérez, Cristóbal Marshall, Mark D. Leung, Helen O. Schnell, Melanie |
author_sort | Domingos, Sérgio R. |
collection | PubMed |
description | The capabilities of rotational spectroscopy-based methods as tools to deliver accurate and precise chirality-sensitive information are still breaking ground, but their applicability in the challenging field of analytical chemistry is already clear. In this mini review, we explore the current abilities and challenges of two emergent techniques for chiral analysis based on rotational spectroscopy. For that, we will showcase the two methods (microwave 3-wave mixing and chiral tag rotational spectroscopy) while testing their performance to solve the absolute configuration and the enantiomeric excess of a blind sample containing a mixture of enantiomers of styrene oxide. |
format | Online Article Text |
id | pubmed-8162261 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-81622612021-06-11 Assessing the performance of rotational spectroscopy in chiral analysis Domingos, Sérgio R. Pérez, Cristóbal Marshall, Mark D. Leung, Helen O. Schnell, Melanie Chem Sci Chemistry The capabilities of rotational spectroscopy-based methods as tools to deliver accurate and precise chirality-sensitive information are still breaking ground, but their applicability in the challenging field of analytical chemistry is already clear. In this mini review, we explore the current abilities and challenges of two emergent techniques for chiral analysis based on rotational spectroscopy. For that, we will showcase the two methods (microwave 3-wave mixing and chiral tag rotational spectroscopy) while testing their performance to solve the absolute configuration and the enantiomeric excess of a blind sample containing a mixture of enantiomers of styrene oxide. The Royal Society of Chemistry 2020-09-28 /pmc/articles/PMC8162261/ /pubmed/34123188 http://dx.doi.org/10.1039/d0sc03752d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Domingos, Sérgio R. Pérez, Cristóbal Marshall, Mark D. Leung, Helen O. Schnell, Melanie Assessing the performance of rotational spectroscopy in chiral analysis |
title | Assessing the performance of rotational spectroscopy in chiral analysis |
title_full | Assessing the performance of rotational spectroscopy in chiral analysis |
title_fullStr | Assessing the performance of rotational spectroscopy in chiral analysis |
title_full_unstemmed | Assessing the performance of rotational spectroscopy in chiral analysis |
title_short | Assessing the performance of rotational spectroscopy in chiral analysis |
title_sort | assessing the performance of rotational spectroscopy in chiral analysis |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162261/ https://www.ncbi.nlm.nih.gov/pubmed/34123188 http://dx.doi.org/10.1039/d0sc03752d |
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