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Assessing the performance of rotational spectroscopy in chiral analysis

The capabilities of rotational spectroscopy-based methods as tools to deliver accurate and precise chirality-sensitive information are still breaking ground, but their applicability in the challenging field of analytical chemistry is already clear. In this mini review, we explore the current abiliti...

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Autores principales: Domingos, Sérgio R., Pérez, Cristóbal, Marshall, Mark D., Leung, Helen O., Schnell, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162261/
https://www.ncbi.nlm.nih.gov/pubmed/34123188
http://dx.doi.org/10.1039/d0sc03752d
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author Domingos, Sérgio R.
Pérez, Cristóbal
Marshall, Mark D.
Leung, Helen O.
Schnell, Melanie
author_facet Domingos, Sérgio R.
Pérez, Cristóbal
Marshall, Mark D.
Leung, Helen O.
Schnell, Melanie
author_sort Domingos, Sérgio R.
collection PubMed
description The capabilities of rotational spectroscopy-based methods as tools to deliver accurate and precise chirality-sensitive information are still breaking ground, but their applicability in the challenging field of analytical chemistry is already clear. In this mini review, we explore the current abilities and challenges of two emergent techniques for chiral analysis based on rotational spectroscopy. For that, we will showcase the two methods (microwave 3-wave mixing and chiral tag rotational spectroscopy) while testing their performance to solve the absolute configuration and the enantiomeric excess of a blind sample containing a mixture of enantiomers of styrene oxide.
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spelling pubmed-81622612021-06-11 Assessing the performance of rotational spectroscopy in chiral analysis Domingos, Sérgio R. Pérez, Cristóbal Marshall, Mark D. Leung, Helen O. Schnell, Melanie Chem Sci Chemistry The capabilities of rotational spectroscopy-based methods as tools to deliver accurate and precise chirality-sensitive information are still breaking ground, but their applicability in the challenging field of analytical chemistry is already clear. In this mini review, we explore the current abilities and challenges of two emergent techniques for chiral analysis based on rotational spectroscopy. For that, we will showcase the two methods (microwave 3-wave mixing and chiral tag rotational spectroscopy) while testing their performance to solve the absolute configuration and the enantiomeric excess of a blind sample containing a mixture of enantiomers of styrene oxide. The Royal Society of Chemistry 2020-09-28 /pmc/articles/PMC8162261/ /pubmed/34123188 http://dx.doi.org/10.1039/d0sc03752d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Domingos, Sérgio R.
Pérez, Cristóbal
Marshall, Mark D.
Leung, Helen O.
Schnell, Melanie
Assessing the performance of rotational spectroscopy in chiral analysis
title Assessing the performance of rotational spectroscopy in chiral analysis
title_full Assessing the performance of rotational spectroscopy in chiral analysis
title_fullStr Assessing the performance of rotational spectroscopy in chiral analysis
title_full_unstemmed Assessing the performance of rotational spectroscopy in chiral analysis
title_short Assessing the performance of rotational spectroscopy in chiral analysis
title_sort assessing the performance of rotational spectroscopy in chiral analysis
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162261/
https://www.ncbi.nlm.nih.gov/pubmed/34123188
http://dx.doi.org/10.1039/d0sc03752d
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