Synthetic methodology towards allylic trans-cyclooctene-ethers enables modification of carbohydrates: bioorthogonal manipulation of the lac repressor

The inverse electron-demand Diels–Alder (IEDDA) pyridazine elimination is one of the key bioorthogonal bond-breaking reactions. In this reaction trans-cyclooctene (TCO) serves as a tetrazine responsive caging moiety for amines, carboxylic acids and alcohols. One issue to date has been the lack of sy...

Descripción completa

Detalles Bibliográficos
Autores principales: de Geus, Mark A. R., Groenewold, G. J. Mirjam, Maurits, Elmer, Araman, Can, van Kasteren, Sander I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162276/
https://www.ncbi.nlm.nih.gov/pubmed/34094281
http://dx.doi.org/10.1039/d0sc03216f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162276/
https://www.ncbi.nlm.nih.gov/pubmed/34094281
http://dx.doi.org/10.1039/d0sc03216f

Ejemplares similares