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Synthetic methodology towards allylic trans-cyclooctene-ethers enables modification of carbohydrates: bioorthogonal manipulation of the lac repressor
The inverse electron-demand Diels–Alder (IEDDA) pyridazine elimination is one of the key bioorthogonal bond-breaking reactions. In this reaction trans-cyclooctene (TCO) serves as a tetrazine responsive caging moiety for amines, carboxylic acids and alcohols. One issue to date has been the lack of sy...
Autores principales: | de Geus, Mark A. R., Groenewold, G. J. Mirjam, Maurits, Elmer, Araman, Can, van Kasteren, Sander I. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162276/ https://www.ncbi.nlm.nih.gov/pubmed/34094281 http://dx.doi.org/10.1039/d0sc03216f |
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