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Inhibitor and substrate cooperate to inhibit amyloid fibril elongation of α-synuclein

In amyloid fibril elongation, soluble growth substrate binds to the fibril-end and converts into the fibril conformation. This process is targeted by inhibitors that block fibril-ends. Here, we investigated how the elongation of α-synuclein (αS) fibrils, which are associated with Parkinson's di...

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Detalles Bibliográficos
Autores principales:	Agerschou, Emil Dandanell, Borgmann, Vera, Wördehoff, Michael M., Hoyer, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162328/ https://www.ncbi.nlm.nih.gov/pubmed/34094375 http://dx.doi.org/10.1039/d0sc04051g

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