A modular and divergent approach to spirocyclic pyrrolidines

An efficient three-step sequence to afford a valuable class of spirocyclic pyrrolidines is reported. A reductive cleavage/Horner–Wadsworth–Emmons cascade facilitates the spirocyclisation of a range of isoxazolines bearing a distal β-ketophosphonate. The spirocyclisation precursors are elaborated in...

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Detalles Bibliográficos
Autores principales: Shennan, Benjamin D. A., Smith, Peter W., Ogura, Yusuke, Dixon, Darren J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162384/
https://www.ncbi.nlm.nih.gov/pubmed/34094297
http://dx.doi.org/10.1039/d0sc03676e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162384/
https://www.ncbi.nlm.nih.gov/pubmed/34094297
http://dx.doi.org/10.1039/d0sc03676e

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