Two-in-one strategy for fluorene-based spirocycles via Pd(0)-catalyzed spiroannulation of o-iodobiaryls with bromonaphthols

Rapid assembly of fluorene-based spirocycles represents a highly significant but challenging task in organic synthesis. Reported herein is a novel Pd(0)-catalyzed [4+1] spiroannulation of simple o-iodobiaryls with bromonaphthols for the one-step construction of [4,5]-spirofluorenes in high yields wi...

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Detalles Bibliográficos
Autores principales: Tan, Bojun, Liu, Long, Zheng, Huayu, Cheng, Tianyi, Zhu, Dianhu, Yang, Xiaofeng, Luan, Xinjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162402/
https://www.ncbi.nlm.nih.gov/pubmed/34094284
http://dx.doi.org/10.1039/d0sc04386a
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author Tan, Bojun
Liu, Long
Zheng, Huayu
Cheng, Tianyi
Zhu, Dianhu
Yang, Xiaofeng
Luan, Xinjun
author_facet Tan, Bojun
Liu, Long
Zheng, Huayu
Cheng, Tianyi
Zhu, Dianhu
Yang, Xiaofeng
Luan, Xinjun
author_sort Tan, Bojun
collection PubMed
description Rapid assembly of fluorene-based spirocycles represents a highly significant but challenging task in organic synthesis. Reported herein is a novel Pd(0)-catalyzed [4+1] spiroannulation of simple o-iodobiaryls with bromonaphthols for the one-step construction of [4,5]-spirofluorenes in high yields with excellent functional group tolerance. Noteworthily, these valuable fluorene-based coumarin skeletons can enrich the database of C-coumarins and exhibit excellent spectroscopic properties.
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spelling pubmed-81624022021-06-04 Two-in-one strategy for fluorene-based spirocycles via Pd(0)-catalyzed spiroannulation of o-iodobiaryls with bromonaphthols Tan, Bojun Liu, Long Zheng, Huayu Cheng, Tianyi Zhu, Dianhu Yang, Xiaofeng Luan, Xinjun Chem Sci Chemistry Rapid assembly of fluorene-based spirocycles represents a highly significant but challenging task in organic synthesis. Reported herein is a novel Pd(0)-catalyzed [4+1] spiroannulation of simple o-iodobiaryls with bromonaphthols for the one-step construction of [4,5]-spirofluorenes in high yields with excellent functional group tolerance. Noteworthily, these valuable fluorene-based coumarin skeletons can enrich the database of C-coumarins and exhibit excellent spectroscopic properties. The Royal Society of Chemistry 2020-09-08 /pmc/articles/PMC8162402/ /pubmed/34094284 http://dx.doi.org/10.1039/d0sc04386a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Tan, Bojun
Liu, Long
Zheng, Huayu
Cheng, Tianyi
Zhu, Dianhu
Yang, Xiaofeng
Luan, Xinjun
Two-in-one strategy for fluorene-based spirocycles via Pd(0)-catalyzed spiroannulation of o-iodobiaryls with bromonaphthols
title Two-in-one strategy for fluorene-based spirocycles via Pd(0)-catalyzed spiroannulation of o-iodobiaryls with bromonaphthols
title_full Two-in-one strategy for fluorene-based spirocycles via Pd(0)-catalyzed spiroannulation of o-iodobiaryls with bromonaphthols
title_fullStr Two-in-one strategy for fluorene-based spirocycles via Pd(0)-catalyzed spiroannulation of o-iodobiaryls with bromonaphthols
title_full_unstemmed Two-in-one strategy for fluorene-based spirocycles via Pd(0)-catalyzed spiroannulation of o-iodobiaryls with bromonaphthols
title_short Two-in-one strategy for fluorene-based spirocycles via Pd(0)-catalyzed spiroannulation of o-iodobiaryls with bromonaphthols
title_sort two-in-one strategy for fluorene-based spirocycles via pd(0)-catalyzed spiroannulation of o-iodobiaryls with bromonaphthols
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162402/
https://www.ncbi.nlm.nih.gov/pubmed/34094284
http://dx.doi.org/10.1039/d0sc04386a
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