Chiral Fe(ii) complex catalyzed enantioselective [1,3] O-to-C rearrangement of alkyl vinyl ethers and synthesis of chromanols and beyond

A highly efficient enantioselective [1,3] O-to-C rearrangement of racemic vinyl ethers that operates under mild conditions was developed. This method with chiral ferrous complex catalyst provided an efficient access to a wide range of chromanols with high yields and excellent enantioselectivities. I...

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Autores principales: Wang, Lifeng, Zhou, Pengfei, Lin, Qianchi, Dong, Shunxi, Liu, Xiaohua, Feng, Xiaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162448/
https://www.ncbi.nlm.nih.gov/pubmed/34094271
http://dx.doi.org/10.1039/d0sc04340k
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author Wang, Lifeng
Zhou, Pengfei
Lin, Qianchi
Dong, Shunxi
Liu, Xiaohua
Feng, Xiaoming
author_facet Wang, Lifeng
Zhou, Pengfei
Lin, Qianchi
Dong, Shunxi
Liu, Xiaohua
Feng, Xiaoming
author_sort Wang, Lifeng
collection PubMed
description A highly efficient enantioselective [1,3] O-to-C rearrangement of racemic vinyl ethers that operates under mild conditions was developed. This method with chiral ferrous complex catalyst provided an efficient access to a wide range of chromanols with high yields and excellent enantioselectivities. In addition, an important urological drug (R)-tolterodine and others were easily obtained after simple transformations.
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spelling pubmed-81624482021-06-04 Chiral Fe(ii) complex catalyzed enantioselective [1,3] O-to-C rearrangement of alkyl vinyl ethers and synthesis of chromanols and beyond Wang, Lifeng Zhou, Pengfei Lin, Qianchi Dong, Shunxi Liu, Xiaohua Feng, Xiaoming Chem Sci Chemistry A highly efficient enantioselective [1,3] O-to-C rearrangement of racemic vinyl ethers that operates under mild conditions was developed. This method with chiral ferrous complex catalyst provided an efficient access to a wide range of chromanols with high yields and excellent enantioselectivities. In addition, an important urological drug (R)-tolterodine and others were easily obtained after simple transformations. The Royal Society of Chemistry 2020-09-07 /pmc/articles/PMC8162448/ /pubmed/34094271 http://dx.doi.org/10.1039/d0sc04340k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Wang, Lifeng
Zhou, Pengfei
Lin, Qianchi
Dong, Shunxi
Liu, Xiaohua
Feng, Xiaoming
Chiral Fe(ii) complex catalyzed enantioselective [1,3] O-to-C rearrangement of alkyl vinyl ethers and synthesis of chromanols and beyond
title Chiral Fe(ii) complex catalyzed enantioselective [1,3] O-to-C rearrangement of alkyl vinyl ethers and synthesis of chromanols and beyond
title_full Chiral Fe(ii) complex catalyzed enantioselective [1,3] O-to-C rearrangement of alkyl vinyl ethers and synthesis of chromanols and beyond
title_fullStr Chiral Fe(ii) complex catalyzed enantioselective [1,3] O-to-C rearrangement of alkyl vinyl ethers and synthesis of chromanols and beyond
title_full_unstemmed Chiral Fe(ii) complex catalyzed enantioselective [1,3] O-to-C rearrangement of alkyl vinyl ethers and synthesis of chromanols and beyond
title_short Chiral Fe(ii) complex catalyzed enantioselective [1,3] O-to-C rearrangement of alkyl vinyl ethers and synthesis of chromanols and beyond
title_sort chiral fe(ii) complex catalyzed enantioselective [1,3] o-to-c rearrangement of alkyl vinyl ethers and synthesis of chromanols and beyond
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162448/
https://www.ncbi.nlm.nih.gov/pubmed/34094271
http://dx.doi.org/10.1039/d0sc04340k
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