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Grafted semiconducting polymer amphiphiles for multimodal optical imaging and combination phototherapy

Semiconducting polymer nanoparticles (SPNs) have gained growing attention in biomedical applications. However, the preparation of SPNs is usually limited to nanoprecipitation in the presence of amphiphilic copolymers, which encounters the issue of dissociation. As an alternative to SPNs, grafted sem...

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Detalles Bibliográficos
Autores principales: Xie, Chen, Zhou, Wen, Zeng, Ziling, Fan, Quli, Pu, Kanyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162460/
https://www.ncbi.nlm.nih.gov/pubmed/34094312
http://dx.doi.org/10.1039/d0sc01721c
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author Xie, Chen
Zhou, Wen
Zeng, Ziling
Fan, Quli
Pu, Kanyi
author_facet Xie, Chen
Zhou, Wen
Zeng, Ziling
Fan, Quli
Pu, Kanyi
author_sort Xie, Chen
collection PubMed
description Semiconducting polymer nanoparticles (SPNs) have gained growing attention in biomedical applications. However, the preparation of SPNs is usually limited to nanoprecipitation in the presence of amphiphilic copolymers, which encounters the issue of dissociation. As an alternative to SPNs, grafted semiconducting polymer amphiphiles (SPAs) composed of a semiconducting polymer (SP) backbone and hydrophilic side chains show increased physiological stability and improved optical properties. This review summarizes recent advances in SPAs for cancer imaging and combination phototherapy. The applications of SPAs in optical imaging including fluorescence, photoacoustic, multimodal and activatable imaging are first described, followed by the discussion of applications in imaging-guided phototherapy and combination therapy, light-triggered drug delivery and gene regulation. At last, the conclusion and future prospects in this field are discussed.
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spelling pubmed-81624602021-06-04 Grafted semiconducting polymer amphiphiles for multimodal optical imaging and combination phototherapy Xie, Chen Zhou, Wen Zeng, Ziling Fan, Quli Pu, Kanyi Chem Sci Chemistry Semiconducting polymer nanoparticles (SPNs) have gained growing attention in biomedical applications. However, the preparation of SPNs is usually limited to nanoprecipitation in the presence of amphiphilic copolymers, which encounters the issue of dissociation. As an alternative to SPNs, grafted semiconducting polymer amphiphiles (SPAs) composed of a semiconducting polymer (SP) backbone and hydrophilic side chains show increased physiological stability and improved optical properties. This review summarizes recent advances in SPAs for cancer imaging and combination phototherapy. The applications of SPAs in optical imaging including fluorescence, photoacoustic, multimodal and activatable imaging are first described, followed by the discussion of applications in imaging-guided phototherapy and combination therapy, light-triggered drug delivery and gene regulation. At last, the conclusion and future prospects in this field are discussed. The Royal Society of Chemistry 2020-07-15 /pmc/articles/PMC8162460/ /pubmed/34094312 http://dx.doi.org/10.1039/d0sc01721c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Xie, Chen
Zhou, Wen
Zeng, Ziling
Fan, Quli
Pu, Kanyi
Grafted semiconducting polymer amphiphiles for multimodal optical imaging and combination phototherapy
title Grafted semiconducting polymer amphiphiles for multimodal optical imaging and combination phototherapy
title_full Grafted semiconducting polymer amphiphiles for multimodal optical imaging and combination phototherapy
title_fullStr Grafted semiconducting polymer amphiphiles for multimodal optical imaging and combination phototherapy
title_full_unstemmed Grafted semiconducting polymer amphiphiles for multimodal optical imaging and combination phototherapy
title_short Grafted semiconducting polymer amphiphiles for multimodal optical imaging and combination phototherapy
title_sort grafted semiconducting polymer amphiphiles for multimodal optical imaging and combination phototherapy
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162460/
https://www.ncbi.nlm.nih.gov/pubmed/34094312
http://dx.doi.org/10.1039/d0sc01721c
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AT fanquli graftedsemiconductingpolymeramphiphilesformultimodalopticalimagingandcombinationphototherapy
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