Cargando…
Prognostic Factors in De Novo Metastatic Renal Cell Carcinoma: A Report From the Latin American Renal Cancer Group
PURPOSE: To assess the effect of clinical and pathological variables on cancer-specific and overall survival (OS) in de novo metastatic patients from a collaborative of primarily Latin American countries. PATIENTS AND METHODS: Of 4,060 patients with renal cell carcinoma diagnosed between 1990 and 20...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162501/ https://www.ncbi.nlm.nih.gov/pubmed/33974442 http://dx.doi.org/10.1200/GO.20.00621 |
_version_ | 1783700727054467072 |
---|---|
author | Abreu, Diego Carvalhal, Gustavo Gueglio, Guillermo Tobia, Ignacio Garcia, Patricio Zuñiga, Alvaro Meza, Luis Bengió, Rubén Scorticati, Carlos Castillejos, Ricardo Rodriguez, Francisco Autran, Ana María Gonzales, Carmen Gadu, Jose Nolazco, Alejandro Ameri, Carlos Zampolli, Hamilton Langenhin, Raúl Muguruza, Diego Machado, Marcos Tobías Mingote, Pablo Yandian, Juan Clavijo, Jorge Nogueira, Lucas Clark, Omar Secin, Fernando Rovegno, Agustín Vilas, Ana Barrios, Enrique Decia, Ricardo Guimarães, Gustavo Glina, Sidney Pal, Sumanta K. Rodriguez, Oscar Palou, Joan Spiess, Philippe Lara, Primo N. Linehan, W. Marston Pastore, Antonio Luigi Zequi, Stenio C. |
author_facet | Abreu, Diego Carvalhal, Gustavo Gueglio, Guillermo Tobia, Ignacio Garcia, Patricio Zuñiga, Alvaro Meza, Luis Bengió, Rubén Scorticati, Carlos Castillejos, Ricardo Rodriguez, Francisco Autran, Ana María Gonzales, Carmen Gadu, Jose Nolazco, Alejandro Ameri, Carlos Zampolli, Hamilton Langenhin, Raúl Muguruza, Diego Machado, Marcos Tobías Mingote, Pablo Yandian, Juan Clavijo, Jorge Nogueira, Lucas Clark, Omar Secin, Fernando Rovegno, Agustín Vilas, Ana Barrios, Enrique Decia, Ricardo Guimarães, Gustavo Glina, Sidney Pal, Sumanta K. Rodriguez, Oscar Palou, Joan Spiess, Philippe Lara, Primo N. Linehan, W. Marston Pastore, Antonio Luigi Zequi, Stenio C. |
author_sort | Abreu, Diego |
collection | PubMed |
description | PURPOSE: To assess the effect of clinical and pathological variables on cancer-specific and overall survival (OS) in de novo metastatic patients from a collaborative of primarily Latin American countries. PATIENTS AND METHODS: Of 4,060 patients with renal cell carcinoma diagnosed between 1990 and 2015, a total of 530 (14.5%) had metastasis at clinical presentation. Relationships between clinical and pathological parameters and treatment-related outcomes were analyzed by Cox regression and the log-rank method. RESULTS: Of 530 patients, 184 (90.6%) had died of renal cell carcinoma. The median OS of the entire cohort was 24 months. American Society of Anesthesiology classification 3-4 (hazard ratio [HR]: 1.64), perirenal fat invasion (HR: 2.02), and ≥ 2 metastatic organ sites (HR: 2.19) were independent prognostic factors for 5-year OS in multivariable analyses. We created a risk group stratification with these variables: no adverse risk factors (favorable group), median OS not reached; one adverse factor (intermediate group), median OS 33 months (HR: 2.04); and two or three adverse factors (poor risk group), median OS 14 months (HR: 3.58). CONCLUSION: Our study defines novel prognostic factors that are relevant to a Latin American cohort. With external validation, these easily discerned clinical variables can be used to offer prognostic information across low- and middle-income countries. |
format | Online Article Text |
id | pubmed-8162501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-81625012021-06-01 Prognostic Factors in De Novo Metastatic Renal Cell Carcinoma: A Report From the Latin American Renal Cancer Group Abreu, Diego Carvalhal, Gustavo Gueglio, Guillermo Tobia, Ignacio Garcia, Patricio Zuñiga, Alvaro Meza, Luis Bengió, Rubén Scorticati, Carlos Castillejos, Ricardo Rodriguez, Francisco Autran, Ana María Gonzales, Carmen Gadu, Jose Nolazco, Alejandro Ameri, Carlos Zampolli, Hamilton Langenhin, Raúl Muguruza, Diego Machado, Marcos Tobías Mingote, Pablo Yandian, Juan Clavijo, Jorge Nogueira, Lucas Clark, Omar Secin, Fernando Rovegno, Agustín Vilas, Ana Barrios, Enrique Decia, Ricardo Guimarães, Gustavo Glina, Sidney Pal, Sumanta K. Rodriguez, Oscar Palou, Joan Spiess, Philippe Lara, Primo N. Linehan, W. Marston Pastore, Antonio Luigi Zequi, Stenio C. JCO Glob Oncol ORIGINAL REPORTS PURPOSE: To assess the effect of clinical and pathological variables on cancer-specific and overall survival (OS) in de novo metastatic patients from a collaborative of primarily Latin American countries. PATIENTS AND METHODS: Of 4,060 patients with renal cell carcinoma diagnosed between 1990 and 2015, a total of 530 (14.5%) had metastasis at clinical presentation. Relationships between clinical and pathological parameters and treatment-related outcomes were analyzed by Cox regression and the log-rank method. RESULTS: Of 530 patients, 184 (90.6%) had died of renal cell carcinoma. The median OS of the entire cohort was 24 months. American Society of Anesthesiology classification 3-4 (hazard ratio [HR]: 1.64), perirenal fat invasion (HR: 2.02), and ≥ 2 metastatic organ sites (HR: 2.19) were independent prognostic factors for 5-year OS in multivariable analyses. We created a risk group stratification with these variables: no adverse risk factors (favorable group), median OS not reached; one adverse factor (intermediate group), median OS 33 months (HR: 2.04); and two or three adverse factors (poor risk group), median OS 14 months (HR: 3.58). CONCLUSION: Our study defines novel prognostic factors that are relevant to a Latin American cohort. With external validation, these easily discerned clinical variables can be used to offer prognostic information across low- and middle-income countries. Wolters Kluwer Health 2021-05-11 /pmc/articles/PMC8162501/ /pubmed/33974442 http://dx.doi.org/10.1200/GO.20.00621 Text en © 2021 by American Society of Clinical Oncology https://creativecommons.org/licenses/by-nc-nd/4.0/Creative Commons Attribution Non-Commercial No Derivatives 4.0 License: https://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | ORIGINAL REPORTS Abreu, Diego Carvalhal, Gustavo Gueglio, Guillermo Tobia, Ignacio Garcia, Patricio Zuñiga, Alvaro Meza, Luis Bengió, Rubén Scorticati, Carlos Castillejos, Ricardo Rodriguez, Francisco Autran, Ana María Gonzales, Carmen Gadu, Jose Nolazco, Alejandro Ameri, Carlos Zampolli, Hamilton Langenhin, Raúl Muguruza, Diego Machado, Marcos Tobías Mingote, Pablo Yandian, Juan Clavijo, Jorge Nogueira, Lucas Clark, Omar Secin, Fernando Rovegno, Agustín Vilas, Ana Barrios, Enrique Decia, Ricardo Guimarães, Gustavo Glina, Sidney Pal, Sumanta K. Rodriguez, Oscar Palou, Joan Spiess, Philippe Lara, Primo N. Linehan, W. Marston Pastore, Antonio Luigi Zequi, Stenio C. Prognostic Factors in De Novo Metastatic Renal Cell Carcinoma: A Report From the Latin American Renal Cancer Group |
title | Prognostic Factors in De Novo Metastatic Renal Cell Carcinoma: A Report From the Latin American Renal Cancer Group |
title_full | Prognostic Factors in De Novo Metastatic Renal Cell Carcinoma: A Report From the Latin American Renal Cancer Group |
title_fullStr | Prognostic Factors in De Novo Metastatic Renal Cell Carcinoma: A Report From the Latin American Renal Cancer Group |
title_full_unstemmed | Prognostic Factors in De Novo Metastatic Renal Cell Carcinoma: A Report From the Latin American Renal Cancer Group |
title_short | Prognostic Factors in De Novo Metastatic Renal Cell Carcinoma: A Report From the Latin American Renal Cancer Group |
title_sort | prognostic factors in de novo metastatic renal cell carcinoma: a report from the latin american renal cancer group |
topic | ORIGINAL REPORTS |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162501/ https://www.ncbi.nlm.nih.gov/pubmed/33974442 http://dx.doi.org/10.1200/GO.20.00621 |
work_keys_str_mv | AT abreudiego prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT carvalhalgustavo prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT gueglioguillermo prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT tobiaignacio prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT garciapatricio prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT zunigaalvaro prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT mezaluis prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT bengioruben prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT scorticaticarlos prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT castillejosricardo prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT rodriguezfrancisco prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT autrananamaria prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT gonzalescarmen prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT gadujose prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT nolazcoalejandro prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT americarlos prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT zampollihamilton prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT langenhinraul prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT muguruzadiego prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT machadomarcostobias prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT mingotepablo prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT yandianjuan prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT clavijojorge prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT nogueiralucas prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT clarkomar prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT secinfernando prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT rovegnoagustin prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT vilasana prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT barriosenrique prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT deciaricardo prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT guimaraesgustavo prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT glinasidney prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT palsumantak prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT rodriguezoscar prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT paloujoan prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT spiessphilippe prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT laraprimon prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT linehanwmarston prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT pastoreantonioluigi prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup AT zequistenioc prognosticfactorsindenovometastaticrenalcellcarcinomaareportfromthelatinamericanrenalcancergroup |