Parental genome unification is highly error-prone in mammalian embryos

Most human embryos are aneuploid. Aneuploidy frequently arises during the early mitotic divisions of the embryo, but its origin remains elusive. Human zygotes that cluster their nucleoli at the pronuclear interface are thought to be more likely to develop into healthy euploid embryos. Here, we show...

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Detalles Bibliográficos
Autores principales: Cavazza, Tommaso, Takeda, Yuko, Politi, Antonio Z., Aushev, Magomet, Aldag, Patrick, Baker, Clara, Choudhary, Meenakshi, Bucevičius, Jonas, Lukinavičius, Gražvydas, Elder, Kay, Blayney, Martyn, Lucas-Hahn, Andrea, Niemann, Heiner, Herbert, Mary, Schuh, Melina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162515/
https://www.ncbi.nlm.nih.gov/pubmed/33964210
http://dx.doi.org/10.1016/j.cell.2021.04.013

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