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Fulminant Guillain–Barré Syndrome Post Hemorrhagic Stroke: Two Case Reports
Guillain–Barré syndrome (GBS) is an acute, immune-mediated inflammatory peripheral polyneuropathy characterized by ascending paralysis. Most GBS cases follow gastrointestinal or chest infections. Some patients have been reported either following or concomitant with head trauma, neurosurgical procedu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162529/ https://www.ncbi.nlm.nih.gov/pubmed/34066316 http://dx.doi.org/10.3390/neurolint13020019 |
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author | Abdulmana, Sameeh Al-Zahrani, Naif Sharahely, Yahya Bashir, Shahid M. Al-Harbi, Talal |
author_facet | Abdulmana, Sameeh Al-Zahrani, Naif Sharahely, Yahya Bashir, Shahid M. Al-Harbi, Talal |
author_sort | Abdulmana, Sameeh |
collection | PubMed |
description | Guillain–Barré syndrome (GBS) is an acute, immune-mediated inflammatory peripheral polyneuropathy characterized by ascending paralysis. Most GBS cases follow gastrointestinal or chest infections. Some patients have been reported either following or concomitant with head trauma, neurosurgical procedures, and rarely hemorrhagic stroke. The exact pathogenesis is not entirely understood. However, blood–brain barrier damage may play an essential role in triggering the autoimmune activation that leads to post-stroke GBS. Here, we present two cases of fulminant GBS following hemorrhagic stroke to remind clinicians to be aware of this rare treatable complication if a stroke patient develops unexplainable flaccid paralysis with or without respiratory distress. |
format | Online Article Text |
id | pubmed-8162529 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81625292021-05-29 Fulminant Guillain–Barré Syndrome Post Hemorrhagic Stroke: Two Case Reports Abdulmana, Sameeh Al-Zahrani, Naif Sharahely, Yahya Bashir, Shahid M. Al-Harbi, Talal Neurol Int Case Report Guillain–Barré syndrome (GBS) is an acute, immune-mediated inflammatory peripheral polyneuropathy characterized by ascending paralysis. Most GBS cases follow gastrointestinal or chest infections. Some patients have been reported either following or concomitant with head trauma, neurosurgical procedures, and rarely hemorrhagic stroke. The exact pathogenesis is not entirely understood. However, blood–brain barrier damage may play an essential role in triggering the autoimmune activation that leads to post-stroke GBS. Here, we present two cases of fulminant GBS following hemorrhagic stroke to remind clinicians to be aware of this rare treatable complication if a stroke patient develops unexplainable flaccid paralysis with or without respiratory distress. MDPI 2021-05-06 /pmc/articles/PMC8162529/ /pubmed/34066316 http://dx.doi.org/10.3390/neurolint13020019 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Abdulmana, Sameeh Al-Zahrani, Naif Sharahely, Yahya Bashir, Shahid M. Al-Harbi, Talal Fulminant Guillain–Barré Syndrome Post Hemorrhagic Stroke: Two Case Reports |
title | Fulminant Guillain–Barré Syndrome Post Hemorrhagic Stroke: Two Case Reports |
title_full | Fulminant Guillain–Barré Syndrome Post Hemorrhagic Stroke: Two Case Reports |
title_fullStr | Fulminant Guillain–Barré Syndrome Post Hemorrhagic Stroke: Two Case Reports |
title_full_unstemmed | Fulminant Guillain–Barré Syndrome Post Hemorrhagic Stroke: Two Case Reports |
title_short | Fulminant Guillain–Barré Syndrome Post Hemorrhagic Stroke: Two Case Reports |
title_sort | fulminant guillain–barré syndrome post hemorrhagic stroke: two case reports |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162529/ https://www.ncbi.nlm.nih.gov/pubmed/34066316 http://dx.doi.org/10.3390/neurolint13020019 |
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