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Emerging Data on the Diversity of Molecular Mechanisms Involving C/D snoRNAs
Box C/D small nucleolar RNAs (C/D snoRNAs) represent an ancient family of small non-coding RNAs that are classically viewed as housekeeping guides for the 2′-O-methylation of ribosomal RNA in Archaea and Eukaryotes. However, an extensive set of studies now argues that they are involved in mechanisms...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162545/ https://www.ncbi.nlm.nih.gov/pubmed/34066559 http://dx.doi.org/10.3390/ncrna7020030 |
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author | Baldini, Laeya Charpentier, Bruno Labialle, Stéphane |
author_facet | Baldini, Laeya Charpentier, Bruno Labialle, Stéphane |
author_sort | Baldini, Laeya |
collection | PubMed |
description | Box C/D small nucleolar RNAs (C/D snoRNAs) represent an ancient family of small non-coding RNAs that are classically viewed as housekeeping guides for the 2′-O-methylation of ribosomal RNA in Archaea and Eukaryotes. However, an extensive set of studies now argues that they are involved in mechanisms that go well beyond this function. Here, we present these pieces of evidence in light of the current comprehension of the molecular mechanisms that control C/D snoRNA expression and function. From this inventory emerges that an accurate description of these activities at a molecular level is required to let the snoRNA field enter in a second age of maturity. |
format | Online Article Text |
id | pubmed-8162545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81625452021-05-29 Emerging Data on the Diversity of Molecular Mechanisms Involving C/D snoRNAs Baldini, Laeya Charpentier, Bruno Labialle, Stéphane Noncoding RNA Review Box C/D small nucleolar RNAs (C/D snoRNAs) represent an ancient family of small non-coding RNAs that are classically viewed as housekeeping guides for the 2′-O-methylation of ribosomal RNA in Archaea and Eukaryotes. However, an extensive set of studies now argues that they are involved in mechanisms that go well beyond this function. Here, we present these pieces of evidence in light of the current comprehension of the molecular mechanisms that control C/D snoRNA expression and function. From this inventory emerges that an accurate description of these activities at a molecular level is required to let the snoRNA field enter in a second age of maturity. MDPI 2021-05-06 /pmc/articles/PMC8162545/ /pubmed/34066559 http://dx.doi.org/10.3390/ncrna7020030 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Baldini, Laeya Charpentier, Bruno Labialle, Stéphane Emerging Data on the Diversity of Molecular Mechanisms Involving C/D snoRNAs |
title | Emerging Data on the Diversity of Molecular Mechanisms Involving C/D snoRNAs |
title_full | Emerging Data on the Diversity of Molecular Mechanisms Involving C/D snoRNAs |
title_fullStr | Emerging Data on the Diversity of Molecular Mechanisms Involving C/D snoRNAs |
title_full_unstemmed | Emerging Data on the Diversity of Molecular Mechanisms Involving C/D snoRNAs |
title_short | Emerging Data on the Diversity of Molecular Mechanisms Involving C/D snoRNAs |
title_sort | emerging data on the diversity of molecular mechanisms involving c/d snornas |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162545/ https://www.ncbi.nlm.nih.gov/pubmed/34066559 http://dx.doi.org/10.3390/ncrna7020030 |
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