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A Case of Primary Ciliary Dyskinesia Caused by a Mutation in OFD1, Which Was Diagnosed Owing to Clostridium difficile Infection

We report a Japanese 5-year-old boy with primary ciliary dyskinesia (PCD) which was diagnosed owing to Clostridium difficile (CD) infection caused by prolonged antibiotic exposure. He had intractable otitis media with effusion (OME) and had abdominal pain and diarrhea for 4 months after starting ant...

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Autores principales: Hasegawa, Rina, Suzuki, Shinji, Nishimata, Shigeo, Kashiwagi, Yasuyo, Inagaki, Natsuko, Kawashima, Hisashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162562/
https://www.ncbi.nlm.nih.gov/pubmed/34068458
http://dx.doi.org/10.3390/pediatric13020033
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author Hasegawa, Rina
Suzuki, Shinji
Nishimata, Shigeo
Kashiwagi, Yasuyo
Inagaki, Natsuko
Kawashima, Hisashi
author_facet Hasegawa, Rina
Suzuki, Shinji
Nishimata, Shigeo
Kashiwagi, Yasuyo
Inagaki, Natsuko
Kawashima, Hisashi
author_sort Hasegawa, Rina
collection PubMed
description We report a Japanese 5-year-old boy with primary ciliary dyskinesia (PCD) which was diagnosed owing to Clostridium difficile (CD) infection caused by prolonged antibiotic exposure. He had intractable otitis media with effusion (OME) and had abdominal pain and diarrhea for 4 months after starting antibiotics administration. His stool contained CD toxin. After vancomycin treatment, his symptoms improved and his stools did not contain CD toxin. His past medical history included frequent pneumonia. We, therefore, performed electron microscopy of the biopsy specimen from his nasal mucosa and genetic testing, and he was diagnosed with PCD. PCD is a rare inherited genetic disease causing ciliary dysfunction, which is very difficult to diagnose because some children without PCD also develop the same symptoms. Therefore, children who have intractable OME, rhinosinusitis, frequent pneumonia, or bronchitis and are taking antibiotics for long periods of time should be checked for underlying diseases, such as PCD.
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spelling pubmed-81625622021-05-29 A Case of Primary Ciliary Dyskinesia Caused by a Mutation in OFD1, Which Was Diagnosed Owing to Clostridium difficile Infection Hasegawa, Rina Suzuki, Shinji Nishimata, Shigeo Kashiwagi, Yasuyo Inagaki, Natsuko Kawashima, Hisashi Pediatr Rep Case Report We report a Japanese 5-year-old boy with primary ciliary dyskinesia (PCD) which was diagnosed owing to Clostridium difficile (CD) infection caused by prolonged antibiotic exposure. He had intractable otitis media with effusion (OME) and had abdominal pain and diarrhea for 4 months after starting antibiotics administration. His stool contained CD toxin. After vancomycin treatment, his symptoms improved and his stools did not contain CD toxin. His past medical history included frequent pneumonia. We, therefore, performed electron microscopy of the biopsy specimen from his nasal mucosa and genetic testing, and he was diagnosed with PCD. PCD is a rare inherited genetic disease causing ciliary dysfunction, which is very difficult to diagnose because some children without PCD also develop the same symptoms. Therefore, children who have intractable OME, rhinosinusitis, frequent pneumonia, or bronchitis and are taking antibiotics for long periods of time should be checked for underlying diseases, such as PCD. MDPI 2021-05-10 /pmc/articles/PMC8162562/ /pubmed/34068458 http://dx.doi.org/10.3390/pediatric13020033 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Hasegawa, Rina
Suzuki, Shinji
Nishimata, Shigeo
Kashiwagi, Yasuyo
Inagaki, Natsuko
Kawashima, Hisashi
A Case of Primary Ciliary Dyskinesia Caused by a Mutation in OFD1, Which Was Diagnosed Owing to Clostridium difficile Infection
title A Case of Primary Ciliary Dyskinesia Caused by a Mutation in OFD1, Which Was Diagnosed Owing to Clostridium difficile Infection
title_full A Case of Primary Ciliary Dyskinesia Caused by a Mutation in OFD1, Which Was Diagnosed Owing to Clostridium difficile Infection
title_fullStr A Case of Primary Ciliary Dyskinesia Caused by a Mutation in OFD1, Which Was Diagnosed Owing to Clostridium difficile Infection
title_full_unstemmed A Case of Primary Ciliary Dyskinesia Caused by a Mutation in OFD1, Which Was Diagnosed Owing to Clostridium difficile Infection
title_short A Case of Primary Ciliary Dyskinesia Caused by a Mutation in OFD1, Which Was Diagnosed Owing to Clostridium difficile Infection
title_sort case of primary ciliary dyskinesia caused by a mutation in ofd1, which was diagnosed owing to clostridium difficile infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162562/
https://www.ncbi.nlm.nih.gov/pubmed/34068458
http://dx.doi.org/10.3390/pediatric13020033
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