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Carbon/nitrogen metabolism and stress response networks – calcium-dependent protein kinases as the missing link?
Calcium-dependent protein kinases (CDPKs) play essential roles in plant development and stress responses. CDPKs have a conserved kinase domain, followed by an auto-inhibitory junction connected to the calmodulin-like domain that binds Ca(2+). These structural features allow CDPKs to decode the dynam...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162629/ https://www.ncbi.nlm.nih.gov/pubmed/33787877 http://dx.doi.org/10.1093/jxb/erab136 |
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author | Alves, Hugo L S Matiolli, Cleverson C Soares, Rafael C Almadanim, M Cecília Oliveira, M Margarida Abreu, Isabel A |
author_facet | Alves, Hugo L S Matiolli, Cleverson C Soares, Rafael C Almadanim, M Cecília Oliveira, M Margarida Abreu, Isabel A |
author_sort | Alves, Hugo L S |
collection | PubMed |
description | Calcium-dependent protein kinases (CDPKs) play essential roles in plant development and stress responses. CDPKs have a conserved kinase domain, followed by an auto-inhibitory junction connected to the calmodulin-like domain that binds Ca(2+). These structural features allow CDPKs to decode the dynamic changes in cytoplasmic Ca(2+) concentrations triggered by hormones and by biotic and abiotic stresses. In response to these signals, CDPKs phosphorylate downstream protein targets to regulate growth and stress responses according to the environmental and developmental circumstances. The latest advances in our understanding of the metabolic, transcriptional, and protein–protein interaction networks involving CDPKs suggest that they have a direct influence on plant carbon/nitrogen (C/N) balance. In this review, we discuss how CDPKs could be key signaling nodes connecting stress responses with metabolic homeostasis, and acting together with the sugar and nutrient signaling hubs SnRK1, HXK1, and TOR to improve plant fitness. |
format | Online Article Text |
id | pubmed-8162629 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-81626292021-06-02 Carbon/nitrogen metabolism and stress response networks – calcium-dependent protein kinases as the missing link? Alves, Hugo L S Matiolli, Cleverson C Soares, Rafael C Almadanim, M Cecília Oliveira, M Margarida Abreu, Isabel A J Exp Bot Darwin Review Calcium-dependent protein kinases (CDPKs) play essential roles in plant development and stress responses. CDPKs have a conserved kinase domain, followed by an auto-inhibitory junction connected to the calmodulin-like domain that binds Ca(2+). These structural features allow CDPKs to decode the dynamic changes in cytoplasmic Ca(2+) concentrations triggered by hormones and by biotic and abiotic stresses. In response to these signals, CDPKs phosphorylate downstream protein targets to regulate growth and stress responses according to the environmental and developmental circumstances. The latest advances in our understanding of the metabolic, transcriptional, and protein–protein interaction networks involving CDPKs suggest that they have a direct influence on plant carbon/nitrogen (C/N) balance. In this review, we discuss how CDPKs could be key signaling nodes connecting stress responses with metabolic homeostasis, and acting together with the sugar and nutrient signaling hubs SnRK1, HXK1, and TOR to improve plant fitness. Oxford University Press 2021-03-31 /pmc/articles/PMC8162629/ /pubmed/33787877 http://dx.doi.org/10.1093/jxb/erab136 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Experimental Biology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Darwin Review Alves, Hugo L S Matiolli, Cleverson C Soares, Rafael C Almadanim, M Cecília Oliveira, M Margarida Abreu, Isabel A Carbon/nitrogen metabolism and stress response networks – calcium-dependent protein kinases as the missing link? |
title | Carbon/nitrogen metabolism and stress response networks – calcium-dependent protein kinases as the missing link? |
title_full | Carbon/nitrogen metabolism and stress response networks – calcium-dependent protein kinases as the missing link? |
title_fullStr | Carbon/nitrogen metabolism and stress response networks – calcium-dependent protein kinases as the missing link? |
title_full_unstemmed | Carbon/nitrogen metabolism and stress response networks – calcium-dependent protein kinases as the missing link? |
title_short | Carbon/nitrogen metabolism and stress response networks – calcium-dependent protein kinases as the missing link? |
title_sort | carbon/nitrogen metabolism and stress response networks – calcium-dependent protein kinases as the missing link? |
topic | Darwin Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162629/ https://www.ncbi.nlm.nih.gov/pubmed/33787877 http://dx.doi.org/10.1093/jxb/erab136 |
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