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Different T cell related immunological profiles in COVID-19 patients compared to healthy controls

In various pathological conditions, cellular immunity plays an important role in immune responses. Among immune cells, T lymphocytes pdomote cellular and humoral responses as well as innate immunity. Therefore, careful investigation of these cells has a significant impact on accurate knowledge in CO...

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Autores principales: Mahmoud Salehi Khesht, Armin, Karpisheh, Vahid, Qubais Saeed, Balsam, Olegovna Zekiy, Angelina, Yapanto, Lis M., Nabi Afjadi, Mohsen, Aksoun, Mohsen, Nasr Esfahani, Maryam, Aghakhani, Fatemeh, Movahed, Mahsa, Joshi, Navneet, Abbaszadeh-Goudarzi, Kazem, Hallaj, Shahin, Ahmadi, Majid, Dolati, Sanam, Mahmoodpoor, Ata, Hashemi, Vida, Jadidi-Niaragh, Farhad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162824/
https://www.ncbi.nlm.nih.gov/pubmed/34091116
http://dx.doi.org/10.1016/j.intimp.2021.107828
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author Mahmoud Salehi Khesht, Armin
Karpisheh, Vahid
Qubais Saeed, Balsam
Olegovna Zekiy, Angelina
Yapanto, Lis M.
Nabi Afjadi, Mohsen
Aksoun, Mohsen
Nasr Esfahani, Maryam
Aghakhani, Fatemeh
Movahed, Mahsa
Joshi, Navneet
Abbaszadeh-Goudarzi, Kazem
Hallaj, Shahin
Ahmadi, Majid
Dolati, Sanam
Mahmoodpoor, Ata
Hashemi, Vida
Jadidi-Niaragh, Farhad
author_facet Mahmoud Salehi Khesht, Armin
Karpisheh, Vahid
Qubais Saeed, Balsam
Olegovna Zekiy, Angelina
Yapanto, Lis M.
Nabi Afjadi, Mohsen
Aksoun, Mohsen
Nasr Esfahani, Maryam
Aghakhani, Fatemeh
Movahed, Mahsa
Joshi, Navneet
Abbaszadeh-Goudarzi, Kazem
Hallaj, Shahin
Ahmadi, Majid
Dolati, Sanam
Mahmoodpoor, Ata
Hashemi, Vida
Jadidi-Niaragh, Farhad
author_sort Mahmoud Salehi Khesht, Armin
collection PubMed
description In various pathological conditions, cellular immunity plays an important role in immune responses. Among immune cells, T lymphocytes pdomote cellular and humoral responses as well as innate immunity. Therefore, careful investigation of these cells has a significant impact on accurate knowledge in COVID-19 disease pathogenesis. In current research, the frequency and function of various T lymphocytes involved in immune responses examined in SARS‐CoV-2 patients with various disease severity compared to normal subjects. In order to make an accurate comparison among patients with various disease severity, this study was performed on asymptomatic recovered cases (n = 20), ICU hospitalized patients (n = 30), non-ICU hospitalized patients (n = 30), and normal subjects (n = 20). To precisely evaluate T cells activity following purification, their cytokine secretion activity was examined. Similarly, immediately after purification of Treg cells, their inhibitory activity on T cells was investigated. The results showed that COVID-19 patients with severe disease (ICU hospitalized patients) not only had a remarkable increase in Th1 and Th17 but also a considerable decrease in Th2 and Treg cells. More importantly, as the IL-17 and IFN-γ secretion was sharply increased in severe disease, the secretion of IL-10 and IL-4 was decreased. Furthermore, the inhibitory activity of Treg cells was reduced in severe disease patients in comparison to other groups. In severe COVID-19 disease, current findings indicate when the inflammatory arm of cellular immunity is significantly increased, a considerable reduction in anti-inflammatory and regulatory arm occurred.
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spelling pubmed-81628242021-06-01 Different T cell related immunological profiles in COVID-19 patients compared to healthy controls Mahmoud Salehi Khesht, Armin Karpisheh, Vahid Qubais Saeed, Balsam Olegovna Zekiy, Angelina Yapanto, Lis M. Nabi Afjadi, Mohsen Aksoun, Mohsen Nasr Esfahani, Maryam Aghakhani, Fatemeh Movahed, Mahsa Joshi, Navneet Abbaszadeh-Goudarzi, Kazem Hallaj, Shahin Ahmadi, Majid Dolati, Sanam Mahmoodpoor, Ata Hashemi, Vida Jadidi-Niaragh, Farhad Int Immunopharmacol Article In various pathological conditions, cellular immunity plays an important role in immune responses. Among immune cells, T lymphocytes pdomote cellular and humoral responses as well as innate immunity. Therefore, careful investigation of these cells has a significant impact on accurate knowledge in COVID-19 disease pathogenesis. In current research, the frequency and function of various T lymphocytes involved in immune responses examined in SARS‐CoV-2 patients with various disease severity compared to normal subjects. In order to make an accurate comparison among patients with various disease severity, this study was performed on asymptomatic recovered cases (n = 20), ICU hospitalized patients (n = 30), non-ICU hospitalized patients (n = 30), and normal subjects (n = 20). To precisely evaluate T cells activity following purification, their cytokine secretion activity was examined. Similarly, immediately after purification of Treg cells, their inhibitory activity on T cells was investigated. The results showed that COVID-19 patients with severe disease (ICU hospitalized patients) not only had a remarkable increase in Th1 and Th17 but also a considerable decrease in Th2 and Treg cells. More importantly, as the IL-17 and IFN-γ secretion was sharply increased in severe disease, the secretion of IL-10 and IL-4 was decreased. Furthermore, the inhibitory activity of Treg cells was reduced in severe disease patients in comparison to other groups. In severe COVID-19 disease, current findings indicate when the inflammatory arm of cellular immunity is significantly increased, a considerable reduction in anti-inflammatory and regulatory arm occurred. Elsevier B.V. 2021-08 2021-05-28 /pmc/articles/PMC8162824/ /pubmed/34091116 http://dx.doi.org/10.1016/j.intimp.2021.107828 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Mahmoud Salehi Khesht, Armin
Karpisheh, Vahid
Qubais Saeed, Balsam
Olegovna Zekiy, Angelina
Yapanto, Lis M.
Nabi Afjadi, Mohsen
Aksoun, Mohsen
Nasr Esfahani, Maryam
Aghakhani, Fatemeh
Movahed, Mahsa
Joshi, Navneet
Abbaszadeh-Goudarzi, Kazem
Hallaj, Shahin
Ahmadi, Majid
Dolati, Sanam
Mahmoodpoor, Ata
Hashemi, Vida
Jadidi-Niaragh, Farhad
Different T cell related immunological profiles in COVID-19 patients compared to healthy controls
title Different T cell related immunological profiles in COVID-19 patients compared to healthy controls
title_full Different T cell related immunological profiles in COVID-19 patients compared to healthy controls
title_fullStr Different T cell related immunological profiles in COVID-19 patients compared to healthy controls
title_full_unstemmed Different T cell related immunological profiles in COVID-19 patients compared to healthy controls
title_short Different T cell related immunological profiles in COVID-19 patients compared to healthy controls
title_sort different t cell related immunological profiles in covid-19 patients compared to healthy controls
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162824/
https://www.ncbi.nlm.nih.gov/pubmed/34091116
http://dx.doi.org/10.1016/j.intimp.2021.107828
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