Visible-light mediated carbonyl trifluoromethylative amination as a practical method for the synthesis of β-trifluoromethyl tertiary alkylamines

We report the development of an operationally straigtforward, visible-light-mediated multicomponent strategy for the construction of β-trifluoromethylated tertiary alkylamines from feedstock aldehydes, secondary amines and a convenient source of trifluoromethyl iodide. The new process does not requi...

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Detalles Bibliográficos
Autores principales: Kolahdouzan, Kavoos, Kumar, Roopender, Gaunt, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162877/
https://www.ncbi.nlm.nih.gov/pubmed/34094424
http://dx.doi.org/10.1039/d0sc04853d
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author Kolahdouzan, Kavoos
Kumar, Roopender
Gaunt, Matthew J.
author_facet Kolahdouzan, Kavoos
Kumar, Roopender
Gaunt, Matthew J.
author_sort Kolahdouzan, Kavoos
collection PubMed
description We report the development of an operationally straigtforward, visible-light-mediated multicomponent strategy for the construction of β-trifluoromethylated tertiary alkylamines from feedstock aldehydes, secondary amines and a convenient source of trifluoromethyl iodide. The new process does not require a photocatalyst, is metal-free, displays a broad functional group tolerance and offers rapid, one-pot access to trifluoromethylated drug-like compounds that will be of interest in medicinal chemistry.
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spelling pubmed-81628772021-06-04 Visible-light mediated carbonyl trifluoromethylative amination as a practical method for the synthesis of β-trifluoromethyl tertiary alkylamines Kolahdouzan, Kavoos Kumar, Roopender Gaunt, Matthew J. Chem Sci Chemistry We report the development of an operationally straigtforward, visible-light-mediated multicomponent strategy for the construction of β-trifluoromethylated tertiary alkylamines from feedstock aldehydes, secondary amines and a convenient source of trifluoromethyl iodide. The new process does not require a photocatalyst, is metal-free, displays a broad functional group tolerance and offers rapid, one-pot access to trifluoromethylated drug-like compounds that will be of interest in medicinal chemistry. The Royal Society of Chemistry 2020-10-09 /pmc/articles/PMC8162877/ /pubmed/34094424 http://dx.doi.org/10.1039/d0sc04853d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Kolahdouzan, Kavoos
Kumar, Roopender
Gaunt, Matthew J.
Visible-light mediated carbonyl trifluoromethylative amination as a practical method for the synthesis of β-trifluoromethyl tertiary alkylamines
title Visible-light mediated carbonyl trifluoromethylative amination as a practical method for the synthesis of β-trifluoromethyl tertiary alkylamines
title_full Visible-light mediated carbonyl trifluoromethylative amination as a practical method for the synthesis of β-trifluoromethyl tertiary alkylamines
title_fullStr Visible-light mediated carbonyl trifluoromethylative amination as a practical method for the synthesis of β-trifluoromethyl tertiary alkylamines
title_full_unstemmed Visible-light mediated carbonyl trifluoromethylative amination as a practical method for the synthesis of β-trifluoromethyl tertiary alkylamines
title_short Visible-light mediated carbonyl trifluoromethylative amination as a practical method for the synthesis of β-trifluoromethyl tertiary alkylamines
title_sort visible-light mediated carbonyl trifluoromethylative amination as a practical method for the synthesis of β-trifluoromethyl tertiary alkylamines
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162877/
https://www.ncbi.nlm.nih.gov/pubmed/34094424
http://dx.doi.org/10.1039/d0sc04853d
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AT kumarroopender visiblelightmediatedcarbonyltrifluoromethylativeaminationasapracticalmethodforthesynthesisofbtrifluoromethyltertiaryalkylamines
AT gauntmatthewj visiblelightmediatedcarbonyltrifluoromethylativeaminationasapracticalmethodforthesynthesisofbtrifluoromethyltertiaryalkylamines

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