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Diverse strategies for transition metal catalyzed distal C(sp(3))–H functionalizations

Transition metal catalyzed C(sp(3))–H functionalization is a rapidly growing field. Despite severe challenges, distal C–H functionalizations of aliphatic molecules by overriding proximal positions have witnessed tremendous progress. While usage of stoichiometric directing groups played a crucial rol...

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Detalles Bibliográficos
Autores principales: Das, Jayabrata, Guin, Srimanta, Maiti, Debabrata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162984/
https://www.ncbi.nlm.nih.gov/pubmed/34094339
http://dx.doi.org/10.1039/d0sc04676k
Descripción
Sumario:Transition metal catalyzed C(sp(3))–H functionalization is a rapidly growing field. Despite severe challenges, distal C–H functionalizations of aliphatic molecules by overriding proximal positions have witnessed tremendous progress. While usage of stoichiometric directing groups played a crucial role, reactions with catalytic transient directing groups or methods without any directing groups are gaining more attention due to their practicality. Various innovative strategies, slowly but steadily, circumvented issues related to remote functionalizations of aliphatic molecules. A systematic compilation has been presented here to provide insights into the recent developments and future challenges in the field. The Present perspective is expected to open up a new dimension and provide an avenue for deep insights into the distal C(sp(3))–H functionalizations that could be applied routinely in various pharmaceutical and agrochemical industries.