The Mechanisms for the Association of Cancer and Esophageal Dysmotility Disorders

Background: Achalasia and other esophageal dysmotility disorders mimicking achalasia can be associated with cancer. This study aimed to review the main mechanisms for which cancer may develop in esophageal dysmotility disorder patients. Methods: A narrative review was performed. Results: The mechani...

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Autores principales: Tustumi, Francisco, de Sousa, Jorge Henrique Bento, Dornelas, Nicolas Medeiros, Rosa, Guilherme Maganha, Steinman, Milton, Bianchi, Edno Tales
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163009/
https://www.ncbi.nlm.nih.gov/pubmed/34064058
http://dx.doi.org/10.3390/medsci9020032
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author Tustumi, Francisco
de Sousa, Jorge Henrique Bento
Dornelas, Nicolas Medeiros
Rosa, Guilherme Maganha
Steinman, Milton
Bianchi, Edno Tales
author_facet Tustumi, Francisco
de Sousa, Jorge Henrique Bento
Dornelas, Nicolas Medeiros
Rosa, Guilherme Maganha
Steinman, Milton
Bianchi, Edno Tales
author_sort Tustumi, Francisco
collection PubMed
description Background: Achalasia and other esophageal dysmotility disorders mimicking achalasia can be associated with cancer. This study aimed to review the main mechanisms for which cancer may develop in esophageal dysmotility disorder patients. Methods: A narrative review was performed. Results: The mechanism for developing squamous cell carcinoma and adenocarcinoma are discussed. Besides, achalasia-like syndromes related to familial KIT-gene mutation and pseudoachalasia are discussed. Conclusions: Knowing the main mechanism for which achalasia can be related to cancer is essential for clinicians to conduct the proper investigation, surveillance, and treatment.
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spelling pubmed-81630092021-05-29 The Mechanisms for the Association of Cancer and Esophageal Dysmotility Disorders Tustumi, Francisco de Sousa, Jorge Henrique Bento Dornelas, Nicolas Medeiros Rosa, Guilherme Maganha Steinman, Milton Bianchi, Edno Tales Med Sci (Basel) Review Background: Achalasia and other esophageal dysmotility disorders mimicking achalasia can be associated with cancer. This study aimed to review the main mechanisms for which cancer may develop in esophageal dysmotility disorder patients. Methods: A narrative review was performed. Results: The mechanism for developing squamous cell carcinoma and adenocarcinoma are discussed. Besides, achalasia-like syndromes related to familial KIT-gene mutation and pseudoachalasia are discussed. Conclusions: Knowing the main mechanism for which achalasia can be related to cancer is essential for clinicians to conduct the proper investigation, surveillance, and treatment. MDPI 2021-05-21 /pmc/articles/PMC8163009/ /pubmed/34064058 http://dx.doi.org/10.3390/medsci9020032 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tustumi, Francisco
de Sousa, Jorge Henrique Bento
Dornelas, Nicolas Medeiros
Rosa, Guilherme Maganha
Steinman, Milton
Bianchi, Edno Tales
The Mechanisms for the Association of Cancer and Esophageal Dysmotility Disorders
title The Mechanisms for the Association of Cancer and Esophageal Dysmotility Disorders
title_full The Mechanisms for the Association of Cancer and Esophageal Dysmotility Disorders
title_fullStr The Mechanisms for the Association of Cancer and Esophageal Dysmotility Disorders
title_full_unstemmed The Mechanisms for the Association of Cancer and Esophageal Dysmotility Disorders
title_short The Mechanisms for the Association of Cancer and Esophageal Dysmotility Disorders
title_sort mechanisms for the association of cancer and esophageal dysmotility disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163009/
https://www.ncbi.nlm.nih.gov/pubmed/34064058
http://dx.doi.org/10.3390/medsci9020032
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