SARS-CoV-2 can recruit a heme metabolite to evade antibody immunity

The coronaviral spike is the dominant viral antigen and the target of neutralizing antibodies. We show that SARS-CoV-2 spike binds biliverdin and bilirubin, the tetrapyrrole products of heme metabolism, with nanomolar affinity. Using cryo–electron microscopy and x-ray crystallography, we mapped the...

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Detalles Bibliográficos
Autores principales: Rosa, Annachiara, Pye, Valerie E., Graham, Carl, Muir, Luke, Seow, Jeffrey, Ng, Kevin W., Cook, Nicola J., Rees-Spear, Chloe, Parker, Eleanor, dos Santos, Mariana Silva, Rosadas, Carolina, Susana, Alberto, Rhys, Hefin, Nans, Andrea, Masino, Laura, Roustan, Chloe, Christodoulou, Evangelos, Ulferts, Rachel, Wrobel, Antoni G., Short, Charlotte-Eve, Fertleman, Michael, Sanders, Rogier W., Heaney, Judith, Spyer, Moira, Kjær, Svend, Riddell, Andy, Malim, Michael H., Beale, Rupert, MacRae, James I., Taylor, Graham P., Nastouli, Eleni, van Gils, Marit J., Rosenthal, Peter B., Pizzato, Massimo, McClure, Myra O., Tedder, Richard S., Kassiotis, George, McCoy, Laura E., Doores, Katie J., Cherepanov, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163077/
https://www.ncbi.nlm.nih.gov/pubmed/33888467
http://dx.doi.org/10.1126/sciadv.abg7607

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