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Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism

BACKGROUND: Hypercortisolism affects calcium and phosphate metabolism in dogs; however, the exact mechanisms are not completely understood. OBJECTIVES: To evaluate circulating concentrations of whole parathormone (wPTH), 25‐hydroxyvitamin D (25‐(OH)D), calcitriol, and fibroblast growth factor‐23 (FG...

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Autores principales: Corsini, Andrea, Dondi, Francesco, Serio, Daria G., Zamagni, Silvia, Golinelli, Stefania, Fernandez, Mercedes, Fracassi, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163130/
https://www.ncbi.nlm.nih.gov/pubmed/33991143
http://dx.doi.org/10.1111/jvim.16143
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author Corsini, Andrea
Dondi, Francesco
Serio, Daria G.
Zamagni, Silvia
Golinelli, Stefania
Fernandez, Mercedes
Fracassi, Federico
author_facet Corsini, Andrea
Dondi, Francesco
Serio, Daria G.
Zamagni, Silvia
Golinelli, Stefania
Fernandez, Mercedes
Fracassi, Federico
author_sort Corsini, Andrea
collection PubMed
description BACKGROUND: Hypercortisolism affects calcium and phosphate metabolism in dogs; however, the exact mechanisms are not completely understood. OBJECTIVES: To evaluate circulating concentrations of whole parathormone (wPTH), 25‐hydroxyvitamin D (25‐(OH)D), calcitriol, and fibroblast growth factor‐23 (FGF‐23) in dogs with naturally occurring hypercortisolism (NOHC) and healthy dogs, and their association with calcium and phosphate homeostasis. ANIMALS: Twenty‐three client‐owned dogs with NOHC, and 12 client or staff‐owned healthy dogs. METHODS: Prospective cross‐sectional study. The circulating concentrations of total calcium, ionized calcium (iCa), phosphate, wPTH, 25‐(OH)D, calcitriol and FGF‐23, and the urinary fractional excretion of phosphate (FEP) and calcium (FECa) were compared between dogs with NOHC before treatment and healthy dogs. RESULTS: Dogs with NOHC had higher mean serum phosphate concentrations (4.81 mg/dL, SD ± 0.71 vs 3.86 mg/dL, SD ± 0.60; P < .001), median FECa (0.43%, range, 0.03‐2.44 vs 0.15%, range, 0.06‐0.35; P = .005), and median serum wPTH concentrations (54.6 pg/mL, range, 23.7‐490 vs 24.6 pg/mL, range, 5.5‐56.4; P = .003) as compared to the controls. Circulating concentrations of total calcium, iCa, and calcitriol and the FEP did not differ between groups, whereas the serum 25‐(OH)D concentrations were lower in dogs with NOHC as compared to the controls (70.2 pg/mL, SD ± 42.3 vs 106.3 pg/mL, SD ± 35.3; P = .02). The dogs with NOHC had lower plasma FGF‐23 concentrations than controls (316.6 pg/mL, range, 120.8‐575.6 vs 448.7 pg/mL, range, 244.8‐753; P = .03). CONCLUSIONS AND CLINICAL IMPORTANCE: Urine loss of calcium and hyperphosphatemia could contribute to the adrenal secondary hyperparathyroidism.
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spelling pubmed-81631302021-06-03 Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism Corsini, Andrea Dondi, Francesco Serio, Daria G. Zamagni, Silvia Golinelli, Stefania Fernandez, Mercedes Fracassi, Federico J Vet Intern Med SMALL ANIMAL BACKGROUND: Hypercortisolism affects calcium and phosphate metabolism in dogs; however, the exact mechanisms are not completely understood. OBJECTIVES: To evaluate circulating concentrations of whole parathormone (wPTH), 25‐hydroxyvitamin D (25‐(OH)D), calcitriol, and fibroblast growth factor‐23 (FGF‐23) in dogs with naturally occurring hypercortisolism (NOHC) and healthy dogs, and their association with calcium and phosphate homeostasis. ANIMALS: Twenty‐three client‐owned dogs with NOHC, and 12 client or staff‐owned healthy dogs. METHODS: Prospective cross‐sectional study. The circulating concentrations of total calcium, ionized calcium (iCa), phosphate, wPTH, 25‐(OH)D, calcitriol and FGF‐23, and the urinary fractional excretion of phosphate (FEP) and calcium (FECa) were compared between dogs with NOHC before treatment and healthy dogs. RESULTS: Dogs with NOHC had higher mean serum phosphate concentrations (4.81 mg/dL, SD ± 0.71 vs 3.86 mg/dL, SD ± 0.60; P < .001), median FECa (0.43%, range, 0.03‐2.44 vs 0.15%, range, 0.06‐0.35; P = .005), and median serum wPTH concentrations (54.6 pg/mL, range, 23.7‐490 vs 24.6 pg/mL, range, 5.5‐56.4; P = .003) as compared to the controls. Circulating concentrations of total calcium, iCa, and calcitriol and the FEP did not differ between groups, whereas the serum 25‐(OH)D concentrations were lower in dogs with NOHC as compared to the controls (70.2 pg/mL, SD ± 42.3 vs 106.3 pg/mL, SD ± 35.3; P = .02). The dogs with NOHC had lower plasma FGF‐23 concentrations than controls (316.6 pg/mL, range, 120.8‐575.6 vs 448.7 pg/mL, range, 244.8‐753; P = .03). CONCLUSIONS AND CLINICAL IMPORTANCE: Urine loss of calcium and hyperphosphatemia could contribute to the adrenal secondary hyperparathyroidism. John Wiley & Sons, Inc. 2021-05-15 2021 /pmc/articles/PMC8163130/ /pubmed/33991143 http://dx.doi.org/10.1111/jvim.16143 Text en © 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle SMALL ANIMAL
Corsini, Andrea
Dondi, Francesco
Serio, Daria G.
Zamagni, Silvia
Golinelli, Stefania
Fernandez, Mercedes
Fracassi, Federico
Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism
title Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism
title_full Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism
title_fullStr Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism
title_full_unstemmed Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism
title_short Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism
title_sort calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163130/
https://www.ncbi.nlm.nih.gov/pubmed/33991143
http://dx.doi.org/10.1111/jvim.16143
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