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Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism
BACKGROUND: Hypercortisolism affects calcium and phosphate metabolism in dogs; however, the exact mechanisms are not completely understood. OBJECTIVES: To evaluate circulating concentrations of whole parathormone (wPTH), 25‐hydroxyvitamin D (25‐(OH)D), calcitriol, and fibroblast growth factor‐23 (FG...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163130/ https://www.ncbi.nlm.nih.gov/pubmed/33991143 http://dx.doi.org/10.1111/jvim.16143 |
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author | Corsini, Andrea Dondi, Francesco Serio, Daria G. Zamagni, Silvia Golinelli, Stefania Fernandez, Mercedes Fracassi, Federico |
author_facet | Corsini, Andrea Dondi, Francesco Serio, Daria G. Zamagni, Silvia Golinelli, Stefania Fernandez, Mercedes Fracassi, Federico |
author_sort | Corsini, Andrea |
collection | PubMed |
description | BACKGROUND: Hypercortisolism affects calcium and phosphate metabolism in dogs; however, the exact mechanisms are not completely understood. OBJECTIVES: To evaluate circulating concentrations of whole parathormone (wPTH), 25‐hydroxyvitamin D (25‐(OH)D), calcitriol, and fibroblast growth factor‐23 (FGF‐23) in dogs with naturally occurring hypercortisolism (NOHC) and healthy dogs, and their association with calcium and phosphate homeostasis. ANIMALS: Twenty‐three client‐owned dogs with NOHC, and 12 client or staff‐owned healthy dogs. METHODS: Prospective cross‐sectional study. The circulating concentrations of total calcium, ionized calcium (iCa), phosphate, wPTH, 25‐(OH)D, calcitriol and FGF‐23, and the urinary fractional excretion of phosphate (FEP) and calcium (FECa) were compared between dogs with NOHC before treatment and healthy dogs. RESULTS: Dogs with NOHC had higher mean serum phosphate concentrations (4.81 mg/dL, SD ± 0.71 vs 3.86 mg/dL, SD ± 0.60; P < .001), median FECa (0.43%, range, 0.03‐2.44 vs 0.15%, range, 0.06‐0.35; P = .005), and median serum wPTH concentrations (54.6 pg/mL, range, 23.7‐490 vs 24.6 pg/mL, range, 5.5‐56.4; P = .003) as compared to the controls. Circulating concentrations of total calcium, iCa, and calcitriol and the FEP did not differ between groups, whereas the serum 25‐(OH)D concentrations were lower in dogs with NOHC as compared to the controls (70.2 pg/mL, SD ± 42.3 vs 106.3 pg/mL, SD ± 35.3; P = .02). The dogs with NOHC had lower plasma FGF‐23 concentrations than controls (316.6 pg/mL, range, 120.8‐575.6 vs 448.7 pg/mL, range, 244.8‐753; P = .03). CONCLUSIONS AND CLINICAL IMPORTANCE: Urine loss of calcium and hyperphosphatemia could contribute to the adrenal secondary hyperparathyroidism. |
format | Online Article Text |
id | pubmed-8163130 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81631302021-06-03 Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism Corsini, Andrea Dondi, Francesco Serio, Daria G. Zamagni, Silvia Golinelli, Stefania Fernandez, Mercedes Fracassi, Federico J Vet Intern Med SMALL ANIMAL BACKGROUND: Hypercortisolism affects calcium and phosphate metabolism in dogs; however, the exact mechanisms are not completely understood. OBJECTIVES: To evaluate circulating concentrations of whole parathormone (wPTH), 25‐hydroxyvitamin D (25‐(OH)D), calcitriol, and fibroblast growth factor‐23 (FGF‐23) in dogs with naturally occurring hypercortisolism (NOHC) and healthy dogs, and their association with calcium and phosphate homeostasis. ANIMALS: Twenty‐three client‐owned dogs with NOHC, and 12 client or staff‐owned healthy dogs. METHODS: Prospective cross‐sectional study. The circulating concentrations of total calcium, ionized calcium (iCa), phosphate, wPTH, 25‐(OH)D, calcitriol and FGF‐23, and the urinary fractional excretion of phosphate (FEP) and calcium (FECa) were compared between dogs with NOHC before treatment and healthy dogs. RESULTS: Dogs with NOHC had higher mean serum phosphate concentrations (4.81 mg/dL, SD ± 0.71 vs 3.86 mg/dL, SD ± 0.60; P < .001), median FECa (0.43%, range, 0.03‐2.44 vs 0.15%, range, 0.06‐0.35; P = .005), and median serum wPTH concentrations (54.6 pg/mL, range, 23.7‐490 vs 24.6 pg/mL, range, 5.5‐56.4; P = .003) as compared to the controls. Circulating concentrations of total calcium, iCa, and calcitriol and the FEP did not differ between groups, whereas the serum 25‐(OH)D concentrations were lower in dogs with NOHC as compared to the controls (70.2 pg/mL, SD ± 42.3 vs 106.3 pg/mL, SD ± 35.3; P = .02). The dogs with NOHC had lower plasma FGF‐23 concentrations than controls (316.6 pg/mL, range, 120.8‐575.6 vs 448.7 pg/mL, range, 244.8‐753; P = .03). CONCLUSIONS AND CLINICAL IMPORTANCE: Urine loss of calcium and hyperphosphatemia could contribute to the adrenal secondary hyperparathyroidism. John Wiley & Sons, Inc. 2021-05-15 2021 /pmc/articles/PMC8163130/ /pubmed/33991143 http://dx.doi.org/10.1111/jvim.16143 Text en © 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | SMALL ANIMAL Corsini, Andrea Dondi, Francesco Serio, Daria G. Zamagni, Silvia Golinelli, Stefania Fernandez, Mercedes Fracassi, Federico Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism |
title | Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism |
title_full | Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism |
title_fullStr | Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism |
title_full_unstemmed | Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism |
title_short | Calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism |
title_sort | calcium and phosphate homeostasis in dogs with newly diagnosed naturally occurring hypercortisolism |
topic | SMALL ANIMAL |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163130/ https://www.ncbi.nlm.nih.gov/pubmed/33991143 http://dx.doi.org/10.1111/jvim.16143 |
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