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Western Diet Induced Remodelling of the Tongue Proteome
The tongue is a heavily innervated and vascularized striated muscle that plays an important role in vocalization, swallowing and digestion. The surface of the tongue is lined with papillae which contain gustatory cells expressing various taste receptors. There is growing evidence to suggest that our...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163156/ https://www.ncbi.nlm.nih.gov/pubmed/34066295 http://dx.doi.org/10.3390/proteomes9020022 |
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author | Dutt, Mriga Ng, Yaan-Kit Molendijk, Jeffrey Karimkhanloo, Hamzeh Liao, Luoping Blazev, Ronnie Montgomery, Magdalene K. Watt, Matthew J. Parker, Benjamin L. |
author_facet | Dutt, Mriga Ng, Yaan-Kit Molendijk, Jeffrey Karimkhanloo, Hamzeh Liao, Luoping Blazev, Ronnie Montgomery, Magdalene K. Watt, Matthew J. Parker, Benjamin L. |
author_sort | Dutt, Mriga |
collection | PubMed |
description | The tongue is a heavily innervated and vascularized striated muscle that plays an important role in vocalization, swallowing and digestion. The surface of the tongue is lined with papillae which contain gustatory cells expressing various taste receptors. There is growing evidence to suggest that our perceptions of taste and food preference are remodelled following chronic consumption of Western diets rich in carbohydrate and fats. Our sensitivity to taste and also to metabolising Western diets may be a key factor in the rising prevalence of obesity; however, a systems-wide analysis of the tongue is lacking. Here, we defined the proteomic landscape of the mouse tongue and quantified changes following chronic consumption of a chow or Western diet enriched in lipid, fructose and cholesterol for 7 months. We observed a dramatic remodelling of the tongue proteome including proteins that regulate fatty acid and mitochondrial metabolism. Furthermore, the expressions of several receptors, metabolic enzymes and hormones were differentially regulated, and are likely to provide novel therapeutic targets to alter taste perception and food preference to combat obesity. |
format | Online Article Text |
id | pubmed-8163156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81631562021-05-29 Western Diet Induced Remodelling of the Tongue Proteome Dutt, Mriga Ng, Yaan-Kit Molendijk, Jeffrey Karimkhanloo, Hamzeh Liao, Luoping Blazev, Ronnie Montgomery, Magdalene K. Watt, Matthew J. Parker, Benjamin L. Proteomes Article The tongue is a heavily innervated and vascularized striated muscle that plays an important role in vocalization, swallowing and digestion. The surface of the tongue is lined with papillae which contain gustatory cells expressing various taste receptors. There is growing evidence to suggest that our perceptions of taste and food preference are remodelled following chronic consumption of Western diets rich in carbohydrate and fats. Our sensitivity to taste and also to metabolising Western diets may be a key factor in the rising prevalence of obesity; however, a systems-wide analysis of the tongue is lacking. Here, we defined the proteomic landscape of the mouse tongue and quantified changes following chronic consumption of a chow or Western diet enriched in lipid, fructose and cholesterol for 7 months. We observed a dramatic remodelling of the tongue proteome including proteins that regulate fatty acid and mitochondrial metabolism. Furthermore, the expressions of several receptors, metabolic enzymes and hormones were differentially regulated, and are likely to provide novel therapeutic targets to alter taste perception and food preference to combat obesity. MDPI 2021-05-12 /pmc/articles/PMC8163156/ /pubmed/34066295 http://dx.doi.org/10.3390/proteomes9020022 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Dutt, Mriga Ng, Yaan-Kit Molendijk, Jeffrey Karimkhanloo, Hamzeh Liao, Luoping Blazev, Ronnie Montgomery, Magdalene K. Watt, Matthew J. Parker, Benjamin L. Western Diet Induced Remodelling of the Tongue Proteome |
title | Western Diet Induced Remodelling of the Tongue Proteome |
title_full | Western Diet Induced Remodelling of the Tongue Proteome |
title_fullStr | Western Diet Induced Remodelling of the Tongue Proteome |
title_full_unstemmed | Western Diet Induced Remodelling of the Tongue Proteome |
title_short | Western Diet Induced Remodelling of the Tongue Proteome |
title_sort | western diet induced remodelling of the tongue proteome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163156/ https://www.ncbi.nlm.nih.gov/pubmed/34066295 http://dx.doi.org/10.3390/proteomes9020022 |
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