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Western Diet Induced Remodelling of the Tongue Proteome

The tongue is a heavily innervated and vascularized striated muscle that plays an important role in vocalization, swallowing and digestion. The surface of the tongue is lined with papillae which contain gustatory cells expressing various taste receptors. There is growing evidence to suggest that our...

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Autores principales: Dutt, Mriga, Ng, Yaan-Kit, Molendijk, Jeffrey, Karimkhanloo, Hamzeh, Liao, Luoping, Blazev, Ronnie, Montgomery, Magdalene K., Watt, Matthew J., Parker, Benjamin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163156/
https://www.ncbi.nlm.nih.gov/pubmed/34066295
http://dx.doi.org/10.3390/proteomes9020022
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author Dutt, Mriga
Ng, Yaan-Kit
Molendijk, Jeffrey
Karimkhanloo, Hamzeh
Liao, Luoping
Blazev, Ronnie
Montgomery, Magdalene K.
Watt, Matthew J.
Parker, Benjamin L.
author_facet Dutt, Mriga
Ng, Yaan-Kit
Molendijk, Jeffrey
Karimkhanloo, Hamzeh
Liao, Luoping
Blazev, Ronnie
Montgomery, Magdalene K.
Watt, Matthew J.
Parker, Benjamin L.
author_sort Dutt, Mriga
collection PubMed
description The tongue is a heavily innervated and vascularized striated muscle that plays an important role in vocalization, swallowing and digestion. The surface of the tongue is lined with papillae which contain gustatory cells expressing various taste receptors. There is growing evidence to suggest that our perceptions of taste and food preference are remodelled following chronic consumption of Western diets rich in carbohydrate and fats. Our sensitivity to taste and also to metabolising Western diets may be a key factor in the rising prevalence of obesity; however, a systems-wide analysis of the tongue is lacking. Here, we defined the proteomic landscape of the mouse tongue and quantified changes following chronic consumption of a chow or Western diet enriched in lipid, fructose and cholesterol for 7 months. We observed a dramatic remodelling of the tongue proteome including proteins that regulate fatty acid and mitochondrial metabolism. Furthermore, the expressions of several receptors, metabolic enzymes and hormones were differentially regulated, and are likely to provide novel therapeutic targets to alter taste perception and food preference to combat obesity.
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spelling pubmed-81631562021-05-29 Western Diet Induced Remodelling of the Tongue Proteome Dutt, Mriga Ng, Yaan-Kit Molendijk, Jeffrey Karimkhanloo, Hamzeh Liao, Luoping Blazev, Ronnie Montgomery, Magdalene K. Watt, Matthew J. Parker, Benjamin L. Proteomes Article The tongue is a heavily innervated and vascularized striated muscle that plays an important role in vocalization, swallowing and digestion. The surface of the tongue is lined with papillae which contain gustatory cells expressing various taste receptors. There is growing evidence to suggest that our perceptions of taste and food preference are remodelled following chronic consumption of Western diets rich in carbohydrate and fats. Our sensitivity to taste and also to metabolising Western diets may be a key factor in the rising prevalence of obesity; however, a systems-wide analysis of the tongue is lacking. Here, we defined the proteomic landscape of the mouse tongue and quantified changes following chronic consumption of a chow or Western diet enriched in lipid, fructose and cholesterol for 7 months. We observed a dramatic remodelling of the tongue proteome including proteins that regulate fatty acid and mitochondrial metabolism. Furthermore, the expressions of several receptors, metabolic enzymes and hormones were differentially regulated, and are likely to provide novel therapeutic targets to alter taste perception and food preference to combat obesity. MDPI 2021-05-12 /pmc/articles/PMC8163156/ /pubmed/34066295 http://dx.doi.org/10.3390/proteomes9020022 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dutt, Mriga
Ng, Yaan-Kit
Molendijk, Jeffrey
Karimkhanloo, Hamzeh
Liao, Luoping
Blazev, Ronnie
Montgomery, Magdalene K.
Watt, Matthew J.
Parker, Benjamin L.
Western Diet Induced Remodelling of the Tongue Proteome
title Western Diet Induced Remodelling of the Tongue Proteome
title_full Western Diet Induced Remodelling of the Tongue Proteome
title_fullStr Western Diet Induced Remodelling of the Tongue Proteome
title_full_unstemmed Western Diet Induced Remodelling of the Tongue Proteome
title_short Western Diet Induced Remodelling of the Tongue Proteome
title_sort western diet induced remodelling of the tongue proteome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163156/
https://www.ncbi.nlm.nih.gov/pubmed/34066295
http://dx.doi.org/10.3390/proteomes9020022
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