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National Antibiotic Consumption for Human Use in Sierra Leone (2017–2019): A Cross-Sectional Study

Monitoring antibiotic consumption is crucial to tackling antimicrobial resistance. However, currently there is no system in Sierra Leone for recording and reporting on antibiotic consumption. We therefore conducted a cross-sectional study to assess national antibiotic consumption expressed as define...

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Autores principales: Kanu, Joseph Sam, Khogali, Mohammed, Hann, Katrina, Tao, Wenjing, Barlatt, Shuwary, Komeh, James, Johnson, Joy, Sesay, Mohamed, Vandi, Mohamed Alex, Tweya, Hannock, Timire, Collins, Abiri, Onome Thomas, Thomas, Fawzi, Sankoh-Hughes, Ahmed, Molleh, Bailah, Maruta, Anna, Harries, Anthony D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163174/
https://www.ncbi.nlm.nih.gov/pubmed/34068109
http://dx.doi.org/10.3390/tropicalmed6020077
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author Kanu, Joseph Sam
Khogali, Mohammed
Hann, Katrina
Tao, Wenjing
Barlatt, Shuwary
Komeh, James
Johnson, Joy
Sesay, Mohamed
Vandi, Mohamed Alex
Tweya, Hannock
Timire, Collins
Abiri, Onome Thomas
Thomas, Fawzi
Sankoh-Hughes, Ahmed
Molleh, Bailah
Maruta, Anna
Harries, Anthony D.
author_facet Kanu, Joseph Sam
Khogali, Mohammed
Hann, Katrina
Tao, Wenjing
Barlatt, Shuwary
Komeh, James
Johnson, Joy
Sesay, Mohamed
Vandi, Mohamed Alex
Tweya, Hannock
Timire, Collins
Abiri, Onome Thomas
Thomas, Fawzi
Sankoh-Hughes, Ahmed
Molleh, Bailah
Maruta, Anna
Harries, Anthony D.
author_sort Kanu, Joseph Sam
collection PubMed
description Monitoring antibiotic consumption is crucial to tackling antimicrobial resistance. However, currently there is no system in Sierra Leone for recording and reporting on antibiotic consumption. We therefore conducted a cross-sectional study to assess national antibiotic consumption expressed as defined daily dose (DDD) per 1000 inhabitants per day using all registered and imported antibiotics (categorized under the subgroup J01 under the anatomical and therapeutic classification (ATC) system) as a proxy. Between 2017–2019, total cumulative consumption of antibiotics was 19 DDD per 1000 inhabitants per day. The vast majority consisted of oral antibiotics (98.4%), while parenteral antibiotics made up 1.6%. According to therapeutic/pharmacological subgroups (ATC level 3), beta-lactam/penicillins, quinolones, and other antibacterials (mainly oral metronidazole) comprised 65% of total consumption. According to WHO Access, Watch, and Reserve (AWaRe), 65% of antibiotics consumed were Access, 31% were Watch, and no Reserve antibiotics were reported. The top ten oral antibiotics represented 97% of total oral antibiotics consumed, with metronidazole (35%) and ciprofloxacin (15%) together constituting half of the total. Of parenteral antibiotics consumed, procaine penicillin (32%) and ceftriaxone (19%) together comprised half of the total. Policy recommendations at global and national levels have been made to improve monitoring of antibiotic consumption and antibiotic stewardship.
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spelling pubmed-81631742021-05-29 National Antibiotic Consumption for Human Use in Sierra Leone (2017–2019): A Cross-Sectional Study Kanu, Joseph Sam Khogali, Mohammed Hann, Katrina Tao, Wenjing Barlatt, Shuwary Komeh, James Johnson, Joy Sesay, Mohamed Vandi, Mohamed Alex Tweya, Hannock Timire, Collins Abiri, Onome Thomas Thomas, Fawzi Sankoh-Hughes, Ahmed Molleh, Bailah Maruta, Anna Harries, Anthony D. Trop Med Infect Dis Article Monitoring antibiotic consumption is crucial to tackling antimicrobial resistance. However, currently there is no system in Sierra Leone for recording and reporting on antibiotic consumption. We therefore conducted a cross-sectional study to assess national antibiotic consumption expressed as defined daily dose (DDD) per 1000 inhabitants per day using all registered and imported antibiotics (categorized under the subgroup J01 under the anatomical and therapeutic classification (ATC) system) as a proxy. Between 2017–2019, total cumulative consumption of antibiotics was 19 DDD per 1000 inhabitants per day. The vast majority consisted of oral antibiotics (98.4%), while parenteral antibiotics made up 1.6%. According to therapeutic/pharmacological subgroups (ATC level 3), beta-lactam/penicillins, quinolones, and other antibacterials (mainly oral metronidazole) comprised 65% of total consumption. According to WHO Access, Watch, and Reserve (AWaRe), 65% of antibiotics consumed were Access, 31% were Watch, and no Reserve antibiotics were reported. The top ten oral antibiotics represented 97% of total oral antibiotics consumed, with metronidazole (35%) and ciprofloxacin (15%) together constituting half of the total. Of parenteral antibiotics consumed, procaine penicillin (32%) and ceftriaxone (19%) together comprised half of the total. Policy recommendations at global and national levels have been made to improve monitoring of antibiotic consumption and antibiotic stewardship. MDPI 2021-05-13 /pmc/articles/PMC8163174/ /pubmed/34068109 http://dx.doi.org/10.3390/tropicalmed6020077 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kanu, Joseph Sam
Khogali, Mohammed
Hann, Katrina
Tao, Wenjing
Barlatt, Shuwary
Komeh, James
Johnson, Joy
Sesay, Mohamed
Vandi, Mohamed Alex
Tweya, Hannock
Timire, Collins
Abiri, Onome Thomas
Thomas, Fawzi
Sankoh-Hughes, Ahmed
Molleh, Bailah
Maruta, Anna
Harries, Anthony D.
National Antibiotic Consumption for Human Use in Sierra Leone (2017–2019): A Cross-Sectional Study
title National Antibiotic Consumption for Human Use in Sierra Leone (2017–2019): A Cross-Sectional Study
title_full National Antibiotic Consumption for Human Use in Sierra Leone (2017–2019): A Cross-Sectional Study
title_fullStr National Antibiotic Consumption for Human Use in Sierra Leone (2017–2019): A Cross-Sectional Study
title_full_unstemmed National Antibiotic Consumption for Human Use in Sierra Leone (2017–2019): A Cross-Sectional Study
title_short National Antibiotic Consumption for Human Use in Sierra Leone (2017–2019): A Cross-Sectional Study
title_sort national antibiotic consumption for human use in sierra leone (2017–2019): a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163174/
https://www.ncbi.nlm.nih.gov/pubmed/34068109
http://dx.doi.org/10.3390/tropicalmed6020077
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