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National Antibiotic Consumption for Human Use in Sierra Leone (2017–2019): A Cross-Sectional Study
Monitoring antibiotic consumption is crucial to tackling antimicrobial resistance. However, currently there is no system in Sierra Leone for recording and reporting on antibiotic consumption. We therefore conducted a cross-sectional study to assess national antibiotic consumption expressed as define...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163174/ https://www.ncbi.nlm.nih.gov/pubmed/34068109 http://dx.doi.org/10.3390/tropicalmed6020077 |
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author | Kanu, Joseph Sam Khogali, Mohammed Hann, Katrina Tao, Wenjing Barlatt, Shuwary Komeh, James Johnson, Joy Sesay, Mohamed Vandi, Mohamed Alex Tweya, Hannock Timire, Collins Abiri, Onome Thomas Thomas, Fawzi Sankoh-Hughes, Ahmed Molleh, Bailah Maruta, Anna Harries, Anthony D. |
author_facet | Kanu, Joseph Sam Khogali, Mohammed Hann, Katrina Tao, Wenjing Barlatt, Shuwary Komeh, James Johnson, Joy Sesay, Mohamed Vandi, Mohamed Alex Tweya, Hannock Timire, Collins Abiri, Onome Thomas Thomas, Fawzi Sankoh-Hughes, Ahmed Molleh, Bailah Maruta, Anna Harries, Anthony D. |
author_sort | Kanu, Joseph Sam |
collection | PubMed |
description | Monitoring antibiotic consumption is crucial to tackling antimicrobial resistance. However, currently there is no system in Sierra Leone for recording and reporting on antibiotic consumption. We therefore conducted a cross-sectional study to assess national antibiotic consumption expressed as defined daily dose (DDD) per 1000 inhabitants per day using all registered and imported antibiotics (categorized under the subgroup J01 under the anatomical and therapeutic classification (ATC) system) as a proxy. Between 2017–2019, total cumulative consumption of antibiotics was 19 DDD per 1000 inhabitants per day. The vast majority consisted of oral antibiotics (98.4%), while parenteral antibiotics made up 1.6%. According to therapeutic/pharmacological subgroups (ATC level 3), beta-lactam/penicillins, quinolones, and other antibacterials (mainly oral metronidazole) comprised 65% of total consumption. According to WHO Access, Watch, and Reserve (AWaRe), 65% of antibiotics consumed were Access, 31% were Watch, and no Reserve antibiotics were reported. The top ten oral antibiotics represented 97% of total oral antibiotics consumed, with metronidazole (35%) and ciprofloxacin (15%) together constituting half of the total. Of parenteral antibiotics consumed, procaine penicillin (32%) and ceftriaxone (19%) together comprised half of the total. Policy recommendations at global and national levels have been made to improve monitoring of antibiotic consumption and antibiotic stewardship. |
format | Online Article Text |
id | pubmed-8163174 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81631742021-05-29 National Antibiotic Consumption for Human Use in Sierra Leone (2017–2019): A Cross-Sectional Study Kanu, Joseph Sam Khogali, Mohammed Hann, Katrina Tao, Wenjing Barlatt, Shuwary Komeh, James Johnson, Joy Sesay, Mohamed Vandi, Mohamed Alex Tweya, Hannock Timire, Collins Abiri, Onome Thomas Thomas, Fawzi Sankoh-Hughes, Ahmed Molleh, Bailah Maruta, Anna Harries, Anthony D. Trop Med Infect Dis Article Monitoring antibiotic consumption is crucial to tackling antimicrobial resistance. However, currently there is no system in Sierra Leone for recording and reporting on antibiotic consumption. We therefore conducted a cross-sectional study to assess national antibiotic consumption expressed as defined daily dose (DDD) per 1000 inhabitants per day using all registered and imported antibiotics (categorized under the subgroup J01 under the anatomical and therapeutic classification (ATC) system) as a proxy. Between 2017–2019, total cumulative consumption of antibiotics was 19 DDD per 1000 inhabitants per day. The vast majority consisted of oral antibiotics (98.4%), while parenteral antibiotics made up 1.6%. According to therapeutic/pharmacological subgroups (ATC level 3), beta-lactam/penicillins, quinolones, and other antibacterials (mainly oral metronidazole) comprised 65% of total consumption. According to WHO Access, Watch, and Reserve (AWaRe), 65% of antibiotics consumed were Access, 31% were Watch, and no Reserve antibiotics were reported. The top ten oral antibiotics represented 97% of total oral antibiotics consumed, with metronidazole (35%) and ciprofloxacin (15%) together constituting half of the total. Of parenteral antibiotics consumed, procaine penicillin (32%) and ceftriaxone (19%) together comprised half of the total. Policy recommendations at global and national levels have been made to improve monitoring of antibiotic consumption and antibiotic stewardship. MDPI 2021-05-13 /pmc/articles/PMC8163174/ /pubmed/34068109 http://dx.doi.org/10.3390/tropicalmed6020077 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kanu, Joseph Sam Khogali, Mohammed Hann, Katrina Tao, Wenjing Barlatt, Shuwary Komeh, James Johnson, Joy Sesay, Mohamed Vandi, Mohamed Alex Tweya, Hannock Timire, Collins Abiri, Onome Thomas Thomas, Fawzi Sankoh-Hughes, Ahmed Molleh, Bailah Maruta, Anna Harries, Anthony D. National Antibiotic Consumption for Human Use in Sierra Leone (2017–2019): A Cross-Sectional Study |
title | National Antibiotic Consumption for Human Use in Sierra Leone (2017–2019): A Cross-Sectional Study |
title_full | National Antibiotic Consumption for Human Use in Sierra Leone (2017–2019): A Cross-Sectional Study |
title_fullStr | National Antibiotic Consumption for Human Use in Sierra Leone (2017–2019): A Cross-Sectional Study |
title_full_unstemmed | National Antibiotic Consumption for Human Use in Sierra Leone (2017–2019): A Cross-Sectional Study |
title_short | National Antibiotic Consumption for Human Use in Sierra Leone (2017–2019): A Cross-Sectional Study |
title_sort | national antibiotic consumption for human use in sierra leone (2017–2019): a cross-sectional study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163174/ https://www.ncbi.nlm.nih.gov/pubmed/34068109 http://dx.doi.org/10.3390/tropicalmed6020077 |
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