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Infective Endocarditis in Childhood: a Single-Center Experience of 18 Years
INTRODUCTION: We aimed to present the risk factors, clinical and laboratory findings, treatment management, and risk factors for morbidity and mortality of infective endocarditis (IE) as well as to relate experiences at our center. METHOD: We retrospectively analyzed data of 47 episodes in 45 patien...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Sociedade Brasileira de Cirurgia Cardiovascular
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163273/ https://www.ncbi.nlm.nih.gov/pubmed/33113327 http://dx.doi.org/10.21470/1678-9741-2020-0035 |
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author | Yakut, Kahraman Ecevit, Zafer Tokel, Niyazi Kursad Varan, Birgul Ozkan, Murat |
author_facet | Yakut, Kahraman Ecevit, Zafer Tokel, Niyazi Kursad Varan, Birgul Ozkan, Murat |
author_sort | Yakut, Kahraman |
collection | PubMed |
description | INTRODUCTION: We aimed to present the risk factors, clinical and laboratory findings, treatment management, and risk factors for morbidity and mortality of infective endocarditis (IE) as well as to relate experiences at our center. METHOD: We retrospectively analyzed data of 47 episodes in 45 patients diagnosed with definite/possible IE according to the modified Duke criteria between May 2000 and March 2018. RESULTS: The mean age of all patients at the time of diagnosis was 7.6±4.7 years (range: 2.4 months to 16 years). The most common symptoms and findings were fever (89.3%), leukocytosis (80.8%), splenomegaly (70.2%), and a new heart murmur or changing of pre-existing murmur (68%). Streptococcus viridans (19.1%), Staphylococcus aureus (14.8%), and coagulase-negative Staphylococci (10.6%) were the most commonly isolated agents. IE-related complications developed in 27.6% of the patients and the mortality rate was 14.8%. CONCLUSION: We found that congenital heart disease remains a significant risk factor for IE. The highest risk groups included operated patients who had conduits in the pulmonary position and unoperated patients with a large ventricular septal defect. Surgical intervention was required in most of the patients. Mortality rate was high, especially in patients infected with S. aureus, although the time between the onset of the first symptom and diagnosis was short. Patients with fever and a high risk of IE should be carefully examined for IE, and evaluation in favor of IE until proven otherwise will be more accurate. In high-risk patients with prolonged fever, IE should be considered in the differential diagnosis. |
format | Online Article Text |
id | pubmed-8163273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
record_format | MEDLINE/PubMed |
spelling | pubmed-81632732021-06-07 Infective Endocarditis in Childhood: a Single-Center Experience of 18 Years Yakut, Kahraman Ecevit, Zafer Tokel, Niyazi Kursad Varan, Birgul Ozkan, Murat Braz J Cardiovasc Surg Original Article INTRODUCTION: We aimed to present the risk factors, clinical and laboratory findings, treatment management, and risk factors for morbidity and mortality of infective endocarditis (IE) as well as to relate experiences at our center. METHOD: We retrospectively analyzed data of 47 episodes in 45 patients diagnosed with definite/possible IE according to the modified Duke criteria between May 2000 and March 2018. RESULTS: The mean age of all patients at the time of diagnosis was 7.6±4.7 years (range: 2.4 months to 16 years). The most common symptoms and findings were fever (89.3%), leukocytosis (80.8%), splenomegaly (70.2%), and a new heart murmur or changing of pre-existing murmur (68%). Streptococcus viridans (19.1%), Staphylococcus aureus (14.8%), and coagulase-negative Staphylococci (10.6%) were the most commonly isolated agents. IE-related complications developed in 27.6% of the patients and the mortality rate was 14.8%. CONCLUSION: We found that congenital heart disease remains a significant risk factor for IE. The highest risk groups included operated patients who had conduits in the pulmonary position and unoperated patients with a large ventricular septal defect. Surgical intervention was required in most of the patients. Mortality rate was high, especially in patients infected with S. aureus, although the time between the onset of the first symptom and diagnosis was short. Patients with fever and a high risk of IE should be carefully examined for IE, and evaluation in favor of IE until proven otherwise will be more accurate. In high-risk patients with prolonged fever, IE should be considered in the differential diagnosis. Sociedade Brasileira de Cirurgia Cardiovascular 2021 /pmc/articles/PMC8163273/ /pubmed/33113327 http://dx.doi.org/10.21470/1678-9741-2020-0035 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yakut, Kahraman Ecevit, Zafer Tokel, Niyazi Kursad Varan, Birgul Ozkan, Murat Infective Endocarditis in Childhood: a Single-Center Experience of 18 Years |
title | Infective Endocarditis in Childhood: a Single-Center Experience of 18 Years |
title_full | Infective Endocarditis in Childhood: a Single-Center Experience of 18 Years |
title_fullStr | Infective Endocarditis in Childhood: a Single-Center Experience of 18 Years |
title_full_unstemmed | Infective Endocarditis in Childhood: a Single-Center Experience of 18 Years |
title_short | Infective Endocarditis in Childhood: a Single-Center Experience of 18 Years |
title_sort | infective endocarditis in childhood: a single-center experience of 18 years |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163273/ https://www.ncbi.nlm.nih.gov/pubmed/33113327 http://dx.doi.org/10.21470/1678-9741-2020-0035 |
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