Photo-crosslink analysis in nonribosomal peptide synthetases reveals aberrant gel migration of branched crosslink isomers and spatial proximity between non-neighboring domains

Nonribosomal peptide synthetases (NRPSs) are large, multi-modular enzyme templates for the biosynthesis of important peptide natural products. Modules are composed of a set of semi-autonomous domains that facilitate the individual reaction steps. Only little is known about the existence and relevanc...

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Detalles Bibliográficos
Autores principales: Dehling, Eva, Rüschenbaum, Jennifer, Diecker, Julia, Dörner, Wolfgang, Mootz, Henning D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163358/
https://www.ncbi.nlm.nih.gov/pubmed/34123148
http://dx.doi.org/10.1039/d0sc01969k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163358/
https://www.ncbi.nlm.nih.gov/pubmed/34123148
http://dx.doi.org/10.1039/d0sc01969k

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