A synthetic glycan array containing Cryptococcus neoformans glucuronoxylomannan capsular polysaccharide fragments allows the mapping of protective epitopes

A convergent synthetic strategy to Cryptococcus neoformans glucuronoxylomannan (GXM) capsular polysaccharide part structures was developed based on di-, tri-, tetra-, penta- and hexasaccharide thioglycoside building blocks. The approach permitted the synthesis of a library of spacer-containing serot...

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Detalles Bibliográficos
Autores principales: Guazzelli, Lorenzo, Crawford, Conor J., Ulc, Rebecca, Bowen, Anthony, McCabe, Orla, Jedlicka, Anne J., Wear, Maggie P., Casadevall, Arturo, Oscarson, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163368/
https://www.ncbi.nlm.nih.gov/pubmed/34123169
http://dx.doi.org/10.1039/d0sc01249a

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