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Asymptomatic Familial Multiple Cerebral Cavernous Malformation in a 73-Year-Old Woman

Cerebral cavernous malformations (CCMs) are dilated blood vessels which can develop sporadically or in familial form and are the commonest malformations of blood vessels in the spinal cord and brain. The familial form is an autosomal dominant gene mutation disorder. This condition can be diagnosed w...

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Autores principales: Dzefi-Tettey, Klenam, Edzie, Emmanuel Kobina Mesi, Gorleku, Philip Narteh, Kusodzi, Henry, Asemah, Abdul Raman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163527/
https://www.ncbi.nlm.nih.gov/pubmed/34094613
http://dx.doi.org/10.1155/2021/9974776
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author Dzefi-Tettey, Klenam
Edzie, Emmanuel Kobina Mesi
Gorleku, Philip Narteh
Kusodzi, Henry
Asemah, Abdul Raman
author_facet Dzefi-Tettey, Klenam
Edzie, Emmanuel Kobina Mesi
Gorleku, Philip Narteh
Kusodzi, Henry
Asemah, Abdul Raman
author_sort Dzefi-Tettey, Klenam
collection PubMed
description Cerebral cavernous malformations (CCMs) are dilated blood vessels which can develop sporadically or in familial form and are the commonest malformations of blood vessels in the spinal cord and brain. The familial form is an autosomal dominant gene mutation disorder. This condition can be diagnosed with magnetic resonance imaging (MRI) and computed tomography (CT) scan, but the modality of choice is MRI because of its high sensitivity. We report a case of a 73-year-old woman with an asymptomatic multiple familial cerebral cavernous malformation (FCCM) which was previously misdiagnosed as multiple cerebral metastases on CT scan. A brain MRI performed correctly diagnosed her condition as FCCM based on the typical MRI appearances. In order not to misdiagnose brain lesions like CCM on CT scan, for cerebral metastases in resource-poor settings, radiologists must recommend advanced imaging modalities like MRI for further evaluation, thereby avoiding unnecessary invasive surgical biopsies.
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spelling pubmed-81635272021-06-04 Asymptomatic Familial Multiple Cerebral Cavernous Malformation in a 73-Year-Old Woman Dzefi-Tettey, Klenam Edzie, Emmanuel Kobina Mesi Gorleku, Philip Narteh Kusodzi, Henry Asemah, Abdul Raman Case Rep Radiol Case Report Cerebral cavernous malformations (CCMs) are dilated blood vessels which can develop sporadically or in familial form and are the commonest malformations of blood vessels in the spinal cord and brain. The familial form is an autosomal dominant gene mutation disorder. This condition can be diagnosed with magnetic resonance imaging (MRI) and computed tomography (CT) scan, but the modality of choice is MRI because of its high sensitivity. We report a case of a 73-year-old woman with an asymptomatic multiple familial cerebral cavernous malformation (FCCM) which was previously misdiagnosed as multiple cerebral metastases on CT scan. A brain MRI performed correctly diagnosed her condition as FCCM based on the typical MRI appearances. In order not to misdiagnose brain lesions like CCM on CT scan, for cerebral metastases in resource-poor settings, radiologists must recommend advanced imaging modalities like MRI for further evaluation, thereby avoiding unnecessary invasive surgical biopsies. Hindawi 2021-05-21 /pmc/articles/PMC8163527/ /pubmed/34094613 http://dx.doi.org/10.1155/2021/9974776 Text en Copyright © 2021 Klenam Dzefi-Tettey et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Dzefi-Tettey, Klenam
Edzie, Emmanuel Kobina Mesi
Gorleku, Philip Narteh
Kusodzi, Henry
Asemah, Abdul Raman
Asymptomatic Familial Multiple Cerebral Cavernous Malformation in a 73-Year-Old Woman
title Asymptomatic Familial Multiple Cerebral Cavernous Malformation in a 73-Year-Old Woman
title_full Asymptomatic Familial Multiple Cerebral Cavernous Malformation in a 73-Year-Old Woman
title_fullStr Asymptomatic Familial Multiple Cerebral Cavernous Malformation in a 73-Year-Old Woman
title_full_unstemmed Asymptomatic Familial Multiple Cerebral Cavernous Malformation in a 73-Year-Old Woman
title_short Asymptomatic Familial Multiple Cerebral Cavernous Malformation in a 73-Year-Old Woman
title_sort asymptomatic familial multiple cerebral cavernous malformation in a 73-year-old woman
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163527/
https://www.ncbi.nlm.nih.gov/pubmed/34094613
http://dx.doi.org/10.1155/2021/9974776
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