Geographic distribution and genetic characterization of poxviruses from human infections in Georgia, 2009–2014

Anthrax is endemic in Georgia, as are multiple zoonotic poxviruses. Poxvirus-associated infections share some clinical manifestations and exposure risks with anthrax, and so it is important to distinguish between the two. With this in mind, an archived collection of anthrax-negative DNA samples was...

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Autores principales: Khmaladze, Ekaterine, Mauldin, Matthew R., Tsaguria, Davit, Gavashelidze, Mari, Sidamonidze, Ketevan, Tevdoradze, Tea, Li, Yu, Reynolds, Mary G., Imnadze, Paata, Nakazawa, Yoshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163666/
https://www.ncbi.nlm.nih.gov/pubmed/33745070
http://dx.doi.org/10.1007/s00705-020-04922-x
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author Khmaladze, Ekaterine
Mauldin, Matthew R.
Tsaguria, Davit
Gavashelidze, Mari
Sidamonidze, Ketevan
Tevdoradze, Tea
Li, Yu
Reynolds, Mary G.
Imnadze, Paata
Nakazawa, Yoshinori
author_facet Khmaladze, Ekaterine
Mauldin, Matthew R.
Tsaguria, Davit
Gavashelidze, Mari
Sidamonidze, Ketevan
Tevdoradze, Tea
Li, Yu
Reynolds, Mary G.
Imnadze, Paata
Nakazawa, Yoshinori
author_sort Khmaladze, Ekaterine
collection PubMed
description Anthrax is endemic in Georgia, as are multiple zoonotic poxviruses. Poxvirus-associated infections share some clinical manifestations and exposure risks with anthrax, and so it is important to distinguish between the two. With this in mind, an archived collection of anthrax-negative DNA samples was retrospectively screened for poxviruses, and of the 148 human samples tested, 64 were positive. Sequence analysis confirmed the presence of orf virus, bovine papular stomatitis virus, and pseudocowpox virus. This study provides evidence of previously unrecognized poxvirus infections in Georgia and highlights the benefit of the timely identification of such infections by improving laboratory capacity.
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spelling pubmed-81636662021-06-17 Geographic distribution and genetic characterization of poxviruses from human infections in Georgia, 2009–2014 Khmaladze, Ekaterine Mauldin, Matthew R. Tsaguria, Davit Gavashelidze, Mari Sidamonidze, Ketevan Tevdoradze, Tea Li, Yu Reynolds, Mary G. Imnadze, Paata Nakazawa, Yoshinori Arch Virol Brief Report Anthrax is endemic in Georgia, as are multiple zoonotic poxviruses. Poxvirus-associated infections share some clinical manifestations and exposure risks with anthrax, and so it is important to distinguish between the two. With this in mind, an archived collection of anthrax-negative DNA samples was retrospectively screened for poxviruses, and of the 148 human samples tested, 64 were positive. Sequence analysis confirmed the presence of orf virus, bovine papular stomatitis virus, and pseudocowpox virus. This study provides evidence of previously unrecognized poxvirus infections in Georgia and highlights the benefit of the timely identification of such infections by improving laboratory capacity. Springer Vienna 2021-03-21 2021 /pmc/articles/PMC8163666/ /pubmed/33745070 http://dx.doi.org/10.1007/s00705-020-04922-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Report
Khmaladze, Ekaterine
Mauldin, Matthew R.
Tsaguria, Davit
Gavashelidze, Mari
Sidamonidze, Ketevan
Tevdoradze, Tea
Li, Yu
Reynolds, Mary G.
Imnadze, Paata
Nakazawa, Yoshinori
Geographic distribution and genetic characterization of poxviruses from human infections in Georgia, 2009–2014
title Geographic distribution and genetic characterization of poxviruses from human infections in Georgia, 2009–2014
title_full Geographic distribution and genetic characterization of poxviruses from human infections in Georgia, 2009–2014
title_fullStr Geographic distribution and genetic characterization of poxviruses from human infections in Georgia, 2009–2014
title_full_unstemmed Geographic distribution and genetic characterization of poxviruses from human infections in Georgia, 2009–2014
title_short Geographic distribution and genetic characterization of poxviruses from human infections in Georgia, 2009–2014
title_sort geographic distribution and genetic characterization of poxviruses from human infections in georgia, 2009–2014
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163666/
https://www.ncbi.nlm.nih.gov/pubmed/33745070
http://dx.doi.org/10.1007/s00705-020-04922-x
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