Restoration of energy homeostasis by SIRT6 extends healthy lifespan

Aging leads to a gradual decline in physical activity and disrupted energy homeostasis. The NAD(+)-dependent SIRT6 deacylase regulates aging and metabolism through mechanisms that largely remain unknown. Here, we show that SIRT6 overexpression leads to a reduction in frailty and lifespan extension i...

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Detalles Bibliográficos
Autores principales: Roichman, A., Elhanati, S., Aon, M. A., Abramovich, I., Di Francesco, A., Shahar, Y., Avivi, M. Y., Shurgi, M., Rubinstein, A., Wiesner, Y., Shuchami, A., Petrover, Z., Lebenthal-Loinger, I., Yaron, O., Lyashkov, A., Ubaida-Mohien, C., Kanfi, Y., Lerrer, B., Fernández-Marcos, P. J., Serrano, M., Gottlieb, E., de Cabo, R., Cohen, H. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163764/
https://www.ncbi.nlm.nih.gov/pubmed/34050173
http://dx.doi.org/10.1038/s41467-021-23545-7

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