CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy

Adenosine is an immunosuppressive factor that limits anti-tumor immunity through the suppression of multiple immune subsets including T cells via activation of the adenosine A(2A) receptor (A(2A)R). Using both murine and human chimeric antigen receptor (CAR) T cells, here we show that targeting A(2A...

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Detalles Bibliográficos
Autores principales: Giuffrida, Lauren, Sek, Kevin, Henderson, Melissa A., Lai, Junyun, Chen, Amanda X. Y., Meyran, Deborah, Todd, Kirsten L., Petley, Emma V., Mardiana, Sherly, Mølck, Christina, Stewart, Gregory D., Solomon, Benjamin J., Parish, Ian A., Neeson, Paul J., Harrison, Simon J., Kats, Lev M., House, Imran G., Darcy, Phillip K., Beavis, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163771/
https://www.ncbi.nlm.nih.gov/pubmed/34050151
http://dx.doi.org/10.1038/s41467-021-23331-5

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