hsa_circ_0008234 inhibits the progression of lung adenocarcinoma by sponging miR-574-5p

circRNAs are a novel type of noncoding RNA (ncRNA) that have been identified as an important regulator of gene expression and play a part in the progression of various diseases. However, the function of circ_0008234 in lung adenocarcinoma (LUAC) remains unknown. Through the GEO (Gene Expression Omni...

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Autores principales: Jiang, Wei, He, Yaozhou, Ma, Zijian, Zhang, Yu, Zhang, Chengpeng, Zheng, Nianpeng, Tang, Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163831/
https://www.ncbi.nlm.nih.gov/pubmed/34050132
http://dx.doi.org/10.1038/s41420-021-00512-1
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author Jiang, Wei
He, Yaozhou
Ma, Zijian
Zhang, Yu
Zhang, Chengpeng
Zheng, Nianpeng
Tang, Xing
author_facet Jiang, Wei
He, Yaozhou
Ma, Zijian
Zhang, Yu
Zhang, Chengpeng
Zheng, Nianpeng
Tang, Xing
author_sort Jiang, Wei
collection PubMed
description circRNAs are a novel type of noncoding RNA (ncRNA) that have been identified as an important regulator of gene expression and play a part in the progression of various diseases. However, the function of circ_0008234 in lung adenocarcinoma (LUAC) remains unknown. Through the GEO (Gene Expression Omnibus) database, circ_0008234 was first found to be downregulated in LUAC tissues. It could inhibit cell growth and accelerate apoptosis in vitro and in vivo. In terms of its possible mechanism, circ_0008234 mainly was present in the cytoplasm and competed with miR-574-5p to regulate RND3 (Rho family GTPase 3). Our results revealed that circ_0008234 inhibited the progression of LUAC through a competing endogenous RNA (ceRNA)-based mechanism and provided potential biomarkers and therapeutic targets for LUAC treatment.
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spelling pubmed-81638312021-06-10 hsa_circ_0008234 inhibits the progression of lung adenocarcinoma by sponging miR-574-5p Jiang, Wei He, Yaozhou Ma, Zijian Zhang, Yu Zhang, Chengpeng Zheng, Nianpeng Tang, Xing Cell Death Discov Article circRNAs are a novel type of noncoding RNA (ncRNA) that have been identified as an important regulator of gene expression and play a part in the progression of various diseases. However, the function of circ_0008234 in lung adenocarcinoma (LUAC) remains unknown. Through the GEO (Gene Expression Omnibus) database, circ_0008234 was first found to be downregulated in LUAC tissues. It could inhibit cell growth and accelerate apoptosis in vitro and in vivo. In terms of its possible mechanism, circ_0008234 mainly was present in the cytoplasm and competed with miR-574-5p to regulate RND3 (Rho family GTPase 3). Our results revealed that circ_0008234 inhibited the progression of LUAC through a competing endogenous RNA (ceRNA)-based mechanism and provided potential biomarkers and therapeutic targets for LUAC treatment. Nature Publishing Group UK 2021-05-28 /pmc/articles/PMC8163831/ /pubmed/34050132 http://dx.doi.org/10.1038/s41420-021-00512-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Jiang, Wei
He, Yaozhou
Ma, Zijian
Zhang, Yu
Zhang, Chengpeng
Zheng, Nianpeng
Tang, Xing
hsa_circ_0008234 inhibits the progression of lung adenocarcinoma by sponging miR-574-5p
title hsa_circ_0008234 inhibits the progression of lung adenocarcinoma by sponging miR-574-5p
title_full hsa_circ_0008234 inhibits the progression of lung adenocarcinoma by sponging miR-574-5p
title_fullStr hsa_circ_0008234 inhibits the progression of lung adenocarcinoma by sponging miR-574-5p
title_full_unstemmed hsa_circ_0008234 inhibits the progression of lung adenocarcinoma by sponging miR-574-5p
title_short hsa_circ_0008234 inhibits the progression of lung adenocarcinoma by sponging miR-574-5p
title_sort hsa_circ_0008234 inhibits the progression of lung adenocarcinoma by sponging mir-574-5p
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163831/
https://www.ncbi.nlm.nih.gov/pubmed/34050132
http://dx.doi.org/10.1038/s41420-021-00512-1
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