Cargando…

KLHL38 involvement in non-small cell lung cancer progression via activation of the Akt signaling pathway

Lung cancer is the leading cause of cancer-related death worldwide. KLHL38 has been reported to be upregulated during diapause but downregulated after androgen treatment during the reversal of androgen-dependent skeletal muscle atrophy. This study aimed to clarify the role of KLHL38 in non-small cel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Yitong, Wang, Chenglong, Jiang, Xizi, Zhang, Yao, Su, Hongbo, Jiang, Jun, Ren, Hongjiu, Qiu, Xueshan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163838/ https://www.ncbi.nlm.nih.gov/pubmed/34050138 http://dx.doi.org/10.1038/s41419-021-03835-0

Ejemplares similares

KLHL18 inhibits the proliferation, migration, and invasion of non-small cell lung cancer by inhibiting PI3K/PD-L1 axis activity
por: Jiang, Xizi, et al.
Publicado: (2020)

MKRN2 inhibits migration and invasion of non-small-cell lung cancer by negatively regulating the PI3K/Akt pathway
por: Jiang, Jun, et al.
Publicado: (2018)

JMJD8 Promotes Malignant Progression of Lung Cancer by Maintaining EGFR Stability and EGFR/PI3K/AKT Pathway Activation
por: Zhang, Bo, et al.
Publicado: (2021)

TRIM67 Promotes the Proliferation, Migration, and Invasion of Non-Small-Cell Lung Cancer by Positively Regulating the Notch Pathway
por: Jiang, Jun, et al.
Publicado: (2020)

DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53
por: Wudu, Muli, et al.
Publicado: (2019)

KIAA0247 inhibits growth, migration, invasion of non‐small‐cell lung cancer through regulating the Notch pathway
por: Xu, Yitong, et al.
Publicado: (2018)

TBC1 domain family member 23 interacts with Ras‐related protein Rab‐11A to promote poor prognosis of non‐small‐cell lung cancer via β1‐integrin
por: Zhang, Yao, et al.
Publicado: (2021)

Silencing of CASC8 inhibits non-small cell lung cancer cells function and promotes sensitivity to osimertinib via FOXM1
por: Jiang, Xizi, et al.
Publicado: (2021)

MZT2A promotes NSCLC viability and invasion by increasing Akt phosphorylation via the MOZART2 domain
por: Wang, Huanxi, et al.
Publicado: (2021)

CBLL1 is highly expressed in non‐small cell lung cancer and promotes cell proliferation and invasion
por: Hui, Linping, et al.
Publicado: (2019)

E3 ubiquitin ligase tripartite motif-containing 71 promotes the proliferation of non-small cell lung cancer through the inhibitor of kappaB-α/nuclear factor kappaB pathway
por: Ren, Hongjiu, et al.
Publicado: (2017)

KLHL21, a novel gene that contributes to the progression of hepatocellular carcinoma
por: Shi, Lei, et al.
Publicado: (2016)

Ring finger protein 19A is overexpressed in non‐small cell lung cancer and mediates p53 ubiquitin‐degradation to promote cancer growth
por: Cheng, Yu, et al.
Publicado: (2021)

Clinical Outcome in KLHL24 Cardiomyopathy
por: Vermeer, Mathilde C.S.C., et al.
Publicado: (2023)

Update on the Kelch-like (KLHL) gene family
por: Dhanoa, Bajinder S, et al.
Publicado: (2013)

Overexpression of KLHL23 protein from read‐through transcription of PHOSPHO2‐KLHL23 in gastric cancer increases cell proliferation
por: Choi, Eun‐Seok, et al.
Publicado: (2016)

Crystal Structure of KLHL3 in Complex with Cullin3
por: Ji, Alan X., et al.
Publicado: (2013)

Cardiomyopathy with lethal arrhythmias associated with inactivation of KLHL24
por: Hedberg-Oldfors, Carola, et al.
Publicado: (2019)

A synthetic KLHL20 ligand to validate CUL3(KLHL20) as a potent E3 ligase for targeted protein degradation
por: Farrell, Brian M., et al.
Publicado: (2022)

KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2
por: Chen, Lin, et al.
Publicado: (2023)

The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates Aurora-A
por: Moghe, Saili, et al.
Publicado: (2011)

KLHL5 knockdown increases cellular sensitivity to anticancer drugs
por: Schleifer, Robert J., et al.
Publicado: (2018)

KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination
por: Ramirez-Martinez, Andres, et al.
Publicado: (2017)

Epigenetics of Muscle- and Brain-Specific Expression of KLHL Family Genes
por: Ehrlich, Kenneth C., et al.
Publicado: (2020)

LncRNA HOXC-AS3 promotes non-small-cell lung cancer growth and metastasis through upregulation of YBX1
por: Su, HongBo, et al.
Publicado: (2022)

Cullin3–KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression
por: Zhang, Cen, et al.
Publicado: (2016)

Inner hair cell dysfunction in Klhl18 mutant mice leads to low frequency progressive hearing loss
por: Ingham, Neil J., et al.
Publicado: (2021)

New macular findings in individuals with biallelic KLHL7 gene mutation
por: Heng, Ling Zhi, et al.
Publicado: (2019)

The I510V mutation in KLHL10 in a patient with oligoasthenoteratozoospermia
por: HUANG, Zicong, et al.
Publicado: (2021)

KBTBD7 promotes non‐small cell lung carcinoma progression by enhancing ubiquitin‐dependent degradation of PTEN
por: Zou, Zifang, et al.
Publicado: (2022)

Regulating PLK1 dynamics by Cullin3/KLHL22-mediated ubiquitylation
por: Beck, Jochen, et al.
Publicado: (2013)

Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase
por: Chen, Zhuoyao, et al.
Publicado: (2019)

Cardiac transplant for epidermolysis bullosa simplex with KLHL24 mutation–associated cardiomyopathy
por: Grilletta, Erica Ann
Publicado: (2019)

Role of KLHL3 and dietary K(+) in regulating KS-WNK1 expression
por: Ostrosky-Frid, Mauricio, et al.
Publicado: (2021)

KLHL14: A Novel Prognostic Biomarker and Therapeutic Target for Ovarian Cancer
por: Wang, Xingwei, et al.
Publicado: (2022)

X-linked intellectual disability related to a novel variant of KLHL15
por: Kido, Jun, et al.
Publicado: (2023)

Overexpression of MTA3 Correlates with Tumor Progression in Non-Small Cell Lung Cancer
por: Li, Haiying, et al.
Publicado: (2013)

PDZ-RhoGEF ubiquitination by Cullin3–KLHL20 controls neurotrophin-induced neurite outgrowth
por: Lin, Mei-Yao, et al.
Publicado: (2011)

The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction
por: Ohta, Akihito, et al.
Publicado: (2013)

ZNF452 facilitates tumor proliferation and invasion via activating AKT-GSK3β signaling pathway and predicts poor prognosis of non-small cell lung cancer patients
por: Zhang, Xiupeng, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_5b6avbvsg7p0pjfo64u3fsjghv