Gabapentinoids for Pruritus in Older Adults: A Narrative Review

There is currently no standardized algorithm for the treatment of chronic pruritus (CP), or itch lasting more than 6 weeks, in adults aged ≥ 65 years. The antiepileptic agents gabapentin and pregabalin, however, are gaining popularity in the dermatologic community for their efficacy in treating CP o...

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Detalles Bibliográficos
Autores principales: Sreekantaswamy, Shreya A., Mollanazar, Nicholas, Butler, Daniel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163906/
https://www.ncbi.nlm.nih.gov/pubmed/33721214
http://dx.doi.org/10.1007/s13555-021-00513-z
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author Sreekantaswamy, Shreya A.
Mollanazar, Nicholas
Butler, Daniel C.
author_facet Sreekantaswamy, Shreya A.
Mollanazar, Nicholas
Butler, Daniel C.
author_sort Sreekantaswamy, Shreya A.
collection PubMed
description There is currently no standardized algorithm for the treatment of chronic pruritus (CP), or itch lasting more than 6 weeks, in adults aged ≥ 65 years. The antiepileptic agents gabapentin and pregabalin, however, are gaining popularity in the dermatologic community for their efficacy in treating CP of neuropathic origin. Yet the lack of literature specifically looking at the safety and efficacy of these medications in older adults results in limited guidance for providers in the safe use of gabapentinoids. In this paper we discuss special considerations and recommendations for treating older adults with gabapentin and pregabalin and explore the possibility for these drugs to ameliorate CP of multiple etiologies.
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spelling pubmed-81639062021-06-17 Gabapentinoids for Pruritus in Older Adults: A Narrative Review Sreekantaswamy, Shreya A. Mollanazar, Nicholas Butler, Daniel C. Dermatol Ther (Heidelb) Review There is currently no standardized algorithm for the treatment of chronic pruritus (CP), or itch lasting more than 6 weeks, in adults aged ≥ 65 years. The antiepileptic agents gabapentin and pregabalin, however, are gaining popularity in the dermatologic community for their efficacy in treating CP of neuropathic origin. Yet the lack of literature specifically looking at the safety and efficacy of these medications in older adults results in limited guidance for providers in the safe use of gabapentinoids. In this paper we discuss special considerations and recommendations for treating older adults with gabapentin and pregabalin and explore the possibility for these drugs to ameliorate CP of multiple etiologies. Springer Healthcare 2021-03-15 /pmc/articles/PMC8163906/ /pubmed/33721214 http://dx.doi.org/10.1007/s13555-021-00513-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Review
Sreekantaswamy, Shreya A.
Mollanazar, Nicholas
Butler, Daniel C.
Gabapentinoids for Pruritus in Older Adults: A Narrative Review
title Gabapentinoids for Pruritus in Older Adults: A Narrative Review
title_full Gabapentinoids for Pruritus in Older Adults: A Narrative Review
title_fullStr Gabapentinoids for Pruritus in Older Adults: A Narrative Review
title_full_unstemmed Gabapentinoids for Pruritus in Older Adults: A Narrative Review
title_short Gabapentinoids for Pruritus in Older Adults: A Narrative Review
title_sort gabapentinoids for pruritus in older adults: a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163906/
https://www.ncbi.nlm.nih.gov/pubmed/33721214
http://dx.doi.org/10.1007/s13555-021-00513-z
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