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The deubiquitinating enzyme USP7 regulates the transcription factor Nrf1 by modulating its stability in response to toxic metal exposure

The nuclear factor E2-related factor 1 (Nrf1) transcription factor performs a critical role in regulating cellular homeostasis as part of the cellular stress response and drives the expression of antioxidants and detoxification enzymes among many other functions. Ubiquitination plays an important ro...

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Detalles Bibliográficos
Autores principales:	Han, John J.W., Ho, Daniel V., Kim, Hyun M., Lee, Jun Y., Jeon, Yerin S., Chan, Jefferson Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163974/ https://www.ncbi.nlm.nih.gov/pubmed/33933455 http://dx.doi.org/10.1016/j.jbc.2021.100732

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