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Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism

In Alzheimer's disease (AD), pathological forms of tau are transferred from cell to cell and “seed” aggregation of cytoplasmic tau. Phosphorylation of tau plays a key role in neurodegenerative tauopathies. In addition, apolipoprotein E (apoE), a major component of lipoproteins in the brain, is...

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Detalles Bibliográficos
Autores principales:	Cooper, Joanna M., Lathuiliere, Aurelien, Migliorini, Mary, Arai, Allison L., Wani, Mashhood M., Dujardin, Simon, Muratoglu, Selen C., Hyman, Bradley T., Strickland, Dudley K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164048/ https://www.ncbi.nlm.nih.gov/pubmed/33930462 http://dx.doi.org/10.1016/j.jbc.2021.100715

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