Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial

PURPOSE: Influenza-associated pulmonary aspergillosis (IAPA) is a frequent complication in critically ill influenza patients, associated with significant mortality. We investigated whether antifungal prophylaxis reduces the incidence of IAPA. METHODS: We compared 7 days of intravenous posaconazole (...

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Autores principales: Vanderbeke, Lore, Janssen, Nico A. F., Bergmans, Dennis C. J. J., Bourgeois, Marc, Buil, Jochem B., Debaveye, Yves, Depuydt, Pieter, Feys, Simon, Hermans, Greet, Hoiting, Oscar, van der Hoven, Ben, Jacobs, Cato, Lagrou, Katrien, Lemiale, Virginie, Lormans, Piet, Maertens, Johan, Meersseman, Philippe, Mégarbane, Bruno, Nseir, Saad, van Oers, Jos A. H., Reynders, Marijke, Rijnders, Bart J. A., Schouten, Jeroen A., Spriet, Isabel, Thevissen, Karin, Thille, Arnaud W., Van Daele, Ruth, van de Veerdonk, Frank L., Verweij, Paul E., Wilmer, Alexander, Brüggemann, Roger J. M., Wauters, Joost
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164057/
https://www.ncbi.nlm.nih.gov/pubmed/34050768
http://dx.doi.org/10.1007/s00134-021-06431-0

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