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A traditional medicine, respiratory detox shot (RDS), inhibits the infection of SARS-CoV, SARS-CoV-2, and the influenza A virus in vitro

BACKGROUND: The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has resulted in the infection of over 128 million people and has caused over 2.8 million deaths as of April 2021 in more than 220 countries and territories. Currently, there is no effective treatment for COVID-19 to reduc...

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Autores principales: Hetrick, Brian, Yu, Dongyang, Olanrewaju, Adeyemi A., Chilin, Linda D., He, Sijia, Dabbagh, Deemah, Alluhaibi, Ghaliah, Ma, Yuan-Chun, Hofmann, Lewis A., Hakami, Ramin M., Wu, Yuntao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164078/
https://www.ncbi.nlm.nih.gov/pubmed/34051873
http://dx.doi.org/10.1186/s13578-021-00609-1
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author Hetrick, Brian
Yu, Dongyang
Olanrewaju, Adeyemi A.
Chilin, Linda D.
He, Sijia
Dabbagh, Deemah
Alluhaibi, Ghaliah
Ma, Yuan-Chun
Hofmann, Lewis A.
Hakami, Ramin M.
Wu, Yuntao
author_facet Hetrick, Brian
Yu, Dongyang
Olanrewaju, Adeyemi A.
Chilin, Linda D.
He, Sijia
Dabbagh, Deemah
Alluhaibi, Ghaliah
Ma, Yuan-Chun
Hofmann, Lewis A.
Hakami, Ramin M.
Wu, Yuntao
author_sort Hetrick, Brian
collection PubMed
description BACKGROUND: The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has resulted in the infection of over 128 million people and has caused over 2.8 million deaths as of April 2021 in more than 220 countries and territories. Currently, there is no effective treatment for COVID-19 to reduce mortality. We investigated the potential anti-coronavirus activities from an oral liquid of traditional medicine, Respiratory Detox Shot (RDS), which contains mostly herbal ingredients traditionally used to manage lung diseases. RESULTS: Here we report that RDS inhibited the infection of target cells by lenti-SARS-CoV, lenti-SARS-CoV-2, and hybrid alphavirus-SARS-CoV-2 (Ha-CoV-2) pseudoviruses, and by infectious SARS-CoV-2 and derived Ha-CoV-2 variants including B.1.1.7, B.1.351, P.1, B.1.429, B.1.2, B.1.494, B.1.1.207, B.1.258, and B.1.1.298. We further demonstrated that RDS directly inactivates the infectivity of SARS-CoV-2 virus particles. In addition, we found that RDS can also block the infection of target cells by Influenza A virus. CONCLUSIONS: These results suggest that RDS may broadly inhibit the infection of respiratory viruses.
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spelling pubmed-81640782021-06-01 A traditional medicine, respiratory detox shot (RDS), inhibits the infection of SARS-CoV, SARS-CoV-2, and the influenza A virus in vitro Hetrick, Brian Yu, Dongyang Olanrewaju, Adeyemi A. Chilin, Linda D. He, Sijia Dabbagh, Deemah Alluhaibi, Ghaliah Ma, Yuan-Chun Hofmann, Lewis A. Hakami, Ramin M. Wu, Yuntao Cell Biosci Research BACKGROUND: The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has resulted in the infection of over 128 million people and has caused over 2.8 million deaths as of April 2021 in more than 220 countries and territories. Currently, there is no effective treatment for COVID-19 to reduce mortality. We investigated the potential anti-coronavirus activities from an oral liquid of traditional medicine, Respiratory Detox Shot (RDS), which contains mostly herbal ingredients traditionally used to manage lung diseases. RESULTS: Here we report that RDS inhibited the infection of target cells by lenti-SARS-CoV, lenti-SARS-CoV-2, and hybrid alphavirus-SARS-CoV-2 (Ha-CoV-2) pseudoviruses, and by infectious SARS-CoV-2 and derived Ha-CoV-2 variants including B.1.1.7, B.1.351, P.1, B.1.429, B.1.2, B.1.494, B.1.1.207, B.1.258, and B.1.1.298. We further demonstrated that RDS directly inactivates the infectivity of SARS-CoV-2 virus particles. In addition, we found that RDS can also block the infection of target cells by Influenza A virus. CONCLUSIONS: These results suggest that RDS may broadly inhibit the infection of respiratory viruses. BioMed Central 2021-05-29 /pmc/articles/PMC8164078/ /pubmed/34051873 http://dx.doi.org/10.1186/s13578-021-00609-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Hetrick, Brian
Yu, Dongyang
Olanrewaju, Adeyemi A.
Chilin, Linda D.
He, Sijia
Dabbagh, Deemah
Alluhaibi, Ghaliah
Ma, Yuan-Chun
Hofmann, Lewis A.
Hakami, Ramin M.
Wu, Yuntao
A traditional medicine, respiratory detox shot (RDS), inhibits the infection of SARS-CoV, SARS-CoV-2, and the influenza A virus in vitro
title A traditional medicine, respiratory detox shot (RDS), inhibits the infection of SARS-CoV, SARS-CoV-2, and the influenza A virus in vitro
title_full A traditional medicine, respiratory detox shot (RDS), inhibits the infection of SARS-CoV, SARS-CoV-2, and the influenza A virus in vitro
title_fullStr A traditional medicine, respiratory detox shot (RDS), inhibits the infection of SARS-CoV, SARS-CoV-2, and the influenza A virus in vitro
title_full_unstemmed A traditional medicine, respiratory detox shot (RDS), inhibits the infection of SARS-CoV, SARS-CoV-2, and the influenza A virus in vitro
title_short A traditional medicine, respiratory detox shot (RDS), inhibits the infection of SARS-CoV, SARS-CoV-2, and the influenza A virus in vitro
title_sort traditional medicine, respiratory detox shot (rds), inhibits the infection of sars-cov, sars-cov-2, and the influenza a virus in vitro
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164078/
https://www.ncbi.nlm.nih.gov/pubmed/34051873
http://dx.doi.org/10.1186/s13578-021-00609-1
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