Reduced current density, partially rescued by mexiletine, and depolarizing shift in activation of SCN5A W374G channels as a cause of severe form of Brugada syndrome

BACKGROUND: SCN5A‐related Brugada syndrome (BrS) can be caused by multiple mechanisms including trafficking defects and altered channel gating properties. Most SCN5A mutations at pore region cause trafficking defects, and some of them can be rescued by mexiletine (MEX). OBJECTIVE: We recently encoun...

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Detalles Bibliográficos
Autores principales: Nakajima, Tadashi, Dharmawan, Tommy, Kawabata‐Iwakawa, Reika, Tamura, Shuntaro, Hasegawa, Hiroshi, Kobari, Takashi, Ota, Masaki, Tange, Shoichi, Nishiyama, Masahiko, Kaneko, Yoshiaki, Kurabayashi, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164156/
https://www.ncbi.nlm.nih.gov/pubmed/33463855
http://dx.doi.org/10.1111/anec.12828

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