IgG and IgA autoantibodies against L1 ORF1p expressed in granulocytes correlate with granulocyte consumption and disease activity in pediatric systemic lupus erythematosus

BACKGROUND: Most patients with systemic lupus erythematosus (SLE) have IgG autoantibodies against the RNA-binding p40 (ORF1p) protein encoded by the L1 retroelement. This study tested if these autoantibodies are also present in children with pediatric SLE (pSLE) and if the p40 protein itself could b...

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Autores principales: Ukadike, Kennedy C., Ni, Kathryn, Wang, Xiaoxing, Taylor, Martin S., LaCava, John, Pachman, Lauren M., Eckert, Mary, Stevens, Anne, Lood, Christian, Mustelin, Tomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164314/
https://www.ncbi.nlm.nih.gov/pubmed/34051843
http://dx.doi.org/10.1186/s13075-021-02538-3

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