A Case of Systemic Toxicity Related to Intravesical Bacillus Calmette-Guerin for the Treatment of Bladder Cancer

Intravesical administration of Bacillus Calmette-Guerin (BCG) has been utilized for the treatment of superficial bladder cancer for the past several decades. Though this treatment is well tolerated in general, both local and systematic side effects have been reported. We present a case of a patient...

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Autores principales: Gupta, Sachin, Singh, Balraj, Bhatt, Harshil, Singh, Sandeep, Gupta, Sorab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164525/
https://www.ncbi.nlm.nih.gov/pubmed/34094785
http://dx.doi.org/10.7759/cureus.15321
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author Gupta, Sachin
Singh, Balraj
Bhatt, Harshil
Singh, Sandeep
Gupta, Sorab
author_facet Gupta, Sachin
Singh, Balraj
Bhatt, Harshil
Singh, Sandeep
Gupta, Sorab
author_sort Gupta, Sachin
collection PubMed
description Intravesical administration of Bacillus Calmette-Guerin (BCG) has been utilized for the treatment of superficial bladder cancer for the past several decades. Though this treatment is well tolerated in general, both local and systematic side effects have been reported. We present a case of a patient who presented with systemic symptoms of fever with chills associated with leucopenia, thrombocytopenia, abnormal liver function tests (LFTs), and splenomegaly a few weeks after an episode of traumatic instillation of intravesical BCG. Though the mycobacterial cultures were negative, he was started on an anti-mycobacterial regimen empirically to which he responded and ultimately fully recovered.
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spelling pubmed-81645252021-06-03 A Case of Systemic Toxicity Related to Intravesical Bacillus Calmette-Guerin for the Treatment of Bladder Cancer Gupta, Sachin Singh, Balraj Bhatt, Harshil Singh, Sandeep Gupta, Sorab Cureus Internal Medicine Intravesical administration of Bacillus Calmette-Guerin (BCG) has been utilized for the treatment of superficial bladder cancer for the past several decades. Though this treatment is well tolerated in general, both local and systematic side effects have been reported. We present a case of a patient who presented with systemic symptoms of fever with chills associated with leucopenia, thrombocytopenia, abnormal liver function tests (LFTs), and splenomegaly a few weeks after an episode of traumatic instillation of intravesical BCG. Though the mycobacterial cultures were negative, he was started on an anti-mycobacterial regimen empirically to which he responded and ultimately fully recovered. Cureus 2021-05-29 /pmc/articles/PMC8164525/ /pubmed/34094785 http://dx.doi.org/10.7759/cureus.15321 Text en Copyright © 2021, Gupta et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Gupta, Sachin
Singh, Balraj
Bhatt, Harshil
Singh, Sandeep
Gupta, Sorab
A Case of Systemic Toxicity Related to Intravesical Bacillus Calmette-Guerin for the Treatment of Bladder Cancer
title A Case of Systemic Toxicity Related to Intravesical Bacillus Calmette-Guerin for the Treatment of Bladder Cancer
title_full A Case of Systemic Toxicity Related to Intravesical Bacillus Calmette-Guerin for the Treatment of Bladder Cancer
title_fullStr A Case of Systemic Toxicity Related to Intravesical Bacillus Calmette-Guerin for the Treatment of Bladder Cancer
title_full_unstemmed A Case of Systemic Toxicity Related to Intravesical Bacillus Calmette-Guerin for the Treatment of Bladder Cancer
title_short A Case of Systemic Toxicity Related to Intravesical Bacillus Calmette-Guerin for the Treatment of Bladder Cancer
title_sort case of systemic toxicity related to intravesical bacillus calmette-guerin for the treatment of bladder cancer
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164525/
https://www.ncbi.nlm.nih.gov/pubmed/34094785
http://dx.doi.org/10.7759/cureus.15321
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