Frequency of Aspirin Resistance in Ischemic Stroke Patients and Healthy Controls from Colombia

OBJECTIVE: To evaluate the aspirin resistance prevalence in patients with previous ischemic cerebrovascular disease undergoing aspirin therapy for secondary prevention. MATERIALS AND METHODS: Three hundred fifty patients presenting ischemic strokes and 100 healthy controls under aspirin treatment we...

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Autores principales: Roman-Gonzalez, Alejandro, Naranjo, Carlos Andrés, Cardona-Maya, Walter D., Vallejo, Dionis, Garcia, Francisco, Franco, Cesar, Alvarez, Leonor, Tobón, Luis Ignacio, López, Marta Ibeth, Rua, Carolina, Bedoya, Gabriel, Cadavid, Ángela, Torres, José Domingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164531/
https://www.ncbi.nlm.nih.gov/pubmed/34094500
http://dx.doi.org/10.1155/2021/9924710
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author Roman-Gonzalez, Alejandro
Naranjo, Carlos Andrés
Cardona-Maya, Walter D.
Vallejo, Dionis
Garcia, Francisco
Franco, Cesar
Alvarez, Leonor
Tobón, Luis Ignacio
López, Marta Ibeth
Rua, Carolina
Bedoya, Gabriel
Cadavid, Ángela
Torres, José Domingo
author_facet Roman-Gonzalez, Alejandro
Naranjo, Carlos Andrés
Cardona-Maya, Walter D.
Vallejo, Dionis
Garcia, Francisco
Franco, Cesar
Alvarez, Leonor
Tobón, Luis Ignacio
López, Marta Ibeth
Rua, Carolina
Bedoya, Gabriel
Cadavid, Ángela
Torres, José Domingo
author_sort Roman-Gonzalez, Alejandro
collection PubMed
description OBJECTIVE: To evaluate the aspirin resistance prevalence in patients with previous ischemic cerebrovascular disease undergoing aspirin therapy for secondary prevention. MATERIALS AND METHODS: Three hundred fifty patients presenting ischemic strokes and 100 healthy controls under aspirin treatment were evaluated using the optic platelet aggregation test. RESULTS: Aspirin resistance was found in 7.4% of the patients with ischemic stroke and 4% of controls. Aspirin resistance was associated with stroke recurrence in univariate analysis (p = 0.004). Aspirin resistance was not associated with smoking, diabetes, or hypercholesterolemia. CONCLUSION: Aspirin resistance is present in Colombian patients with ischemic stroke as well as in healthy controls.
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spelling pubmed-81645312021-06-04 Frequency of Aspirin Resistance in Ischemic Stroke Patients and Healthy Controls from Colombia Roman-Gonzalez, Alejandro Naranjo, Carlos Andrés Cardona-Maya, Walter D. Vallejo, Dionis Garcia, Francisco Franco, Cesar Alvarez, Leonor Tobón, Luis Ignacio López, Marta Ibeth Rua, Carolina Bedoya, Gabriel Cadavid, Ángela Torres, José Domingo Stroke Res Treat Research Article OBJECTIVE: To evaluate the aspirin resistance prevalence in patients with previous ischemic cerebrovascular disease undergoing aspirin therapy for secondary prevention. MATERIALS AND METHODS: Three hundred fifty patients presenting ischemic strokes and 100 healthy controls under aspirin treatment were evaluated using the optic platelet aggregation test. RESULTS: Aspirin resistance was found in 7.4% of the patients with ischemic stroke and 4% of controls. Aspirin resistance was associated with stroke recurrence in univariate analysis (p = 0.004). Aspirin resistance was not associated with smoking, diabetes, or hypercholesterolemia. CONCLUSION: Aspirin resistance is present in Colombian patients with ischemic stroke as well as in healthy controls. Hindawi 2021-05-21 /pmc/articles/PMC8164531/ /pubmed/34094500 http://dx.doi.org/10.1155/2021/9924710 Text en Copyright © 2021 Alejandro Roman-Gonzalez et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Roman-Gonzalez, Alejandro
Naranjo, Carlos Andrés
Cardona-Maya, Walter D.
Vallejo, Dionis
Garcia, Francisco
Franco, Cesar
Alvarez, Leonor
Tobón, Luis Ignacio
López, Marta Ibeth
Rua, Carolina
Bedoya, Gabriel
Cadavid, Ángela
Torres, José Domingo
Frequency of Aspirin Resistance in Ischemic Stroke Patients and Healthy Controls from Colombia
title Frequency of Aspirin Resistance in Ischemic Stroke Patients and Healthy Controls from Colombia
title_full Frequency of Aspirin Resistance in Ischemic Stroke Patients and Healthy Controls from Colombia
title_fullStr Frequency of Aspirin Resistance in Ischemic Stroke Patients and Healthy Controls from Colombia
title_full_unstemmed Frequency of Aspirin Resistance in Ischemic Stroke Patients and Healthy Controls from Colombia
title_short Frequency of Aspirin Resistance in Ischemic Stroke Patients and Healthy Controls from Colombia
title_sort frequency of aspirin resistance in ischemic stroke patients and healthy controls from colombia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164531/
https://www.ncbi.nlm.nih.gov/pubmed/34094500
http://dx.doi.org/10.1155/2021/9924710
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