Context-dependent roles of YAP/TAZ in stem cell fates and cancer

Hippo effectors YAP and TAZ control cell fate and survival through various mechanisms, including transcriptional regulation of key genes. However, much of this research has been marked by conflicting results, as well as controversy over whether YAP and TAZ are redundant. A substantial portion of the...

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Autores principales: LeBlanc, Lucy, Ramirez, Nereida, Kim, Jonghwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164607/
https://www.ncbi.nlm.nih.gov/pubmed/33582842
http://dx.doi.org/10.1007/s00018-021-03781-2
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author LeBlanc, Lucy
Ramirez, Nereida
Kim, Jonghwan
author_facet LeBlanc, Lucy
Ramirez, Nereida
Kim, Jonghwan
author_sort LeBlanc, Lucy
collection PubMed
description Hippo effectors YAP and TAZ control cell fate and survival through various mechanisms, including transcriptional regulation of key genes. However, much of this research has been marked by conflicting results, as well as controversy over whether YAP and TAZ are redundant. A substantial portion of the discordance stems from their contradictory roles in stem cell self-renewal vs. differentiation and cancer cell survival vs. apoptosis. In this review, we present an overview of the multiple context-dependent functions of YAP and TAZ in regulating cell fate decisions in stem cells and organoids, as well as their mechanisms of controlling programmed cell death pathways in cancer.
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spelling pubmed-81646072021-06-17 Context-dependent roles of YAP/TAZ in stem cell fates and cancer LeBlanc, Lucy Ramirez, Nereida Kim, Jonghwan Cell Mol Life Sci Review Hippo effectors YAP and TAZ control cell fate and survival through various mechanisms, including transcriptional regulation of key genes. However, much of this research has been marked by conflicting results, as well as controversy over whether YAP and TAZ are redundant. A substantial portion of the discordance stems from their contradictory roles in stem cell self-renewal vs. differentiation and cancer cell survival vs. apoptosis. In this review, we present an overview of the multiple context-dependent functions of YAP and TAZ in regulating cell fate decisions in stem cells and organoids, as well as their mechanisms of controlling programmed cell death pathways in cancer. Springer International Publishing 2021-02-13 2021 /pmc/articles/PMC8164607/ /pubmed/33582842 http://dx.doi.org/10.1007/s00018-021-03781-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
LeBlanc, Lucy
Ramirez, Nereida
Kim, Jonghwan
Context-dependent roles of YAP/TAZ in stem cell fates and cancer
title Context-dependent roles of YAP/TAZ in stem cell fates and cancer
title_full Context-dependent roles of YAP/TAZ in stem cell fates and cancer
title_fullStr Context-dependent roles of YAP/TAZ in stem cell fates and cancer
title_full_unstemmed Context-dependent roles of YAP/TAZ in stem cell fates and cancer
title_short Context-dependent roles of YAP/TAZ in stem cell fates and cancer
title_sort context-dependent roles of yap/taz in stem cell fates and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164607/
https://www.ncbi.nlm.nih.gov/pubmed/33582842
http://dx.doi.org/10.1007/s00018-021-03781-2
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