Cargando…
Surgical and oncological efficacy of laparoscopic-assisted total gastrectomy versus open total gastrectomy for gastric cancer by propensity score matching: a retrospective comparative study
PURPOSE: The application of laparoscopic-assisted total gastrectomy (LATG) for resectable gastric cancer (GC) remains controversial compared with open total gastrectomy (OTG), especially for advanced gastric cancer (AGC) patients according to the inconsistent results demonstrated in the previous stu...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164618/ https://www.ncbi.nlm.nih.gov/pubmed/33415526 http://dx.doi.org/10.1007/s00432-020-03503-4 |
_version_ | 1783701156120231936 |
---|---|
author | Fan, Yingcong Liu, Maoxing Li, Shijie Yu, Jianhong Qi, Xinyu Tan, Fei Xu, Kai Zhang, Nan Yao, Zhendan Yang, Hong Zhang, Chenghai Xing, Jiadi Wang, Zaozao Cui, Ming Su, Xiangqian |
author_facet | Fan, Yingcong Liu, Maoxing Li, Shijie Yu, Jianhong Qi, Xinyu Tan, Fei Xu, Kai Zhang, Nan Yao, Zhendan Yang, Hong Zhang, Chenghai Xing, Jiadi Wang, Zaozao Cui, Ming Su, Xiangqian |
author_sort | Fan, Yingcong |
collection | PubMed |
description | PURPOSE: The application of laparoscopic-assisted total gastrectomy (LATG) for resectable gastric cancer (GC) remains controversial compared with open total gastrectomy (OTG), especially for advanced gastric cancer (AGC) patients according to the inconsistent results demonstrated in the previous studies. The aim of this study was to evaluate the short-term and long-term outcomes between LATG and OTG in a population with more than 80% AGC patients by applying propensity score matching (PSM) method. METHODS: The data of 365 clinical stage I–III GC cases who underwent total gastrectomy with D2 lymphadenectomy were retrospectively collected from January 2011 to April 2018 in the Department of Gastrointestinal Surgery IV of Peking University Cancer Hospital. Propensity scores were generated through taking all covariates into consideration and 131 pairs of patients receiving either LATG or OTG were matched. Intraoperative, postoperative, and survival parameters were compared in the matched groups accordingly. Risk factors for postoperative complications and overall survival were further analyzed. RESULTS: Patient characteristics in the LATG and OTG groups were well balanced after PSM. LATG showed advantages with respect to shorter time to ambulation, first flatus, and first whole liquid diet intake. No significant differences were found between the two groups with regard to postoperative complications as well as overall survival in terms of different pathological stage. Older age was found as an independent risk factor for postoperative complications, and pathological stage for overall survival as well. CONCLUSION: LATG appears to have comparable surgical and oncological safety with OTG by experienced surgeons. |
format | Online Article Text |
id | pubmed-8164618 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-81646182021-06-17 Surgical and oncological efficacy of laparoscopic-assisted total gastrectomy versus open total gastrectomy for gastric cancer by propensity score matching: a retrospective comparative study Fan, Yingcong Liu, Maoxing Li, Shijie Yu, Jianhong Qi, Xinyu Tan, Fei Xu, Kai Zhang, Nan Yao, Zhendan Yang, Hong Zhang, Chenghai Xing, Jiadi Wang, Zaozao Cui, Ming Su, Xiangqian J Cancer Res Clin Oncol Original Article – Clinical Oncology PURPOSE: The application of laparoscopic-assisted total gastrectomy (LATG) for resectable gastric cancer (GC) remains controversial compared with open total gastrectomy (OTG), especially for advanced gastric cancer (AGC) patients according to the inconsistent results demonstrated in the previous studies. The aim of this study was to evaluate the short-term and long-term outcomes between LATG and OTG in a population with more than 80% AGC patients by applying propensity score matching (PSM) method. METHODS: The data of 365 clinical stage I–III GC cases who underwent total gastrectomy with D2 lymphadenectomy were retrospectively collected from January 2011 to April 2018 in the Department of Gastrointestinal Surgery IV of Peking University Cancer Hospital. Propensity scores were generated through taking all covariates into consideration and 131 pairs of patients receiving either LATG or OTG were matched. Intraoperative, postoperative, and survival parameters were compared in the matched groups accordingly. Risk factors for postoperative complications and overall survival were further analyzed. RESULTS: Patient characteristics in the LATG and OTG groups were well balanced after PSM. LATG showed advantages with respect to shorter time to ambulation, first flatus, and first whole liquid diet intake. No significant differences were found between the two groups with regard to postoperative complications as well as overall survival in terms of different pathological stage. Older age was found as an independent risk factor for postoperative complications, and pathological stage for overall survival as well. CONCLUSION: LATG appears to have comparable surgical and oncological safety with OTG by experienced surgeons. Springer Berlin Heidelberg 2021-01-07 2021 /pmc/articles/PMC8164618/ /pubmed/33415526 http://dx.doi.org/10.1007/s00432-020-03503-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article – Clinical Oncology Fan, Yingcong Liu, Maoxing Li, Shijie Yu, Jianhong Qi, Xinyu Tan, Fei Xu, Kai Zhang, Nan Yao, Zhendan Yang, Hong Zhang, Chenghai Xing, Jiadi Wang, Zaozao Cui, Ming Su, Xiangqian Surgical and oncological efficacy of laparoscopic-assisted total gastrectomy versus open total gastrectomy for gastric cancer by propensity score matching: a retrospective comparative study |
title | Surgical and oncological efficacy of laparoscopic-assisted total gastrectomy versus open total gastrectomy for gastric cancer by propensity score matching: a retrospective comparative study |
title_full | Surgical and oncological efficacy of laparoscopic-assisted total gastrectomy versus open total gastrectomy for gastric cancer by propensity score matching: a retrospective comparative study |
title_fullStr | Surgical and oncological efficacy of laparoscopic-assisted total gastrectomy versus open total gastrectomy for gastric cancer by propensity score matching: a retrospective comparative study |
title_full_unstemmed | Surgical and oncological efficacy of laparoscopic-assisted total gastrectomy versus open total gastrectomy for gastric cancer by propensity score matching: a retrospective comparative study |
title_short | Surgical and oncological efficacy of laparoscopic-assisted total gastrectomy versus open total gastrectomy for gastric cancer by propensity score matching: a retrospective comparative study |
title_sort | surgical and oncological efficacy of laparoscopic-assisted total gastrectomy versus open total gastrectomy for gastric cancer by propensity score matching: a retrospective comparative study |
topic | Original Article – Clinical Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164618/ https://www.ncbi.nlm.nih.gov/pubmed/33415526 http://dx.doi.org/10.1007/s00432-020-03503-4 |
work_keys_str_mv | AT fanyingcong surgicalandoncologicalefficacyoflaparoscopicassistedtotalgastrectomyversusopentotalgastrectomyforgastriccancerbypropensityscorematchingaretrospectivecomparativestudy AT liumaoxing surgicalandoncologicalefficacyoflaparoscopicassistedtotalgastrectomyversusopentotalgastrectomyforgastriccancerbypropensityscorematchingaretrospectivecomparativestudy AT lishijie surgicalandoncologicalefficacyoflaparoscopicassistedtotalgastrectomyversusopentotalgastrectomyforgastriccancerbypropensityscorematchingaretrospectivecomparativestudy AT yujianhong surgicalandoncologicalefficacyoflaparoscopicassistedtotalgastrectomyversusopentotalgastrectomyforgastriccancerbypropensityscorematchingaretrospectivecomparativestudy AT qixinyu surgicalandoncologicalefficacyoflaparoscopicassistedtotalgastrectomyversusopentotalgastrectomyforgastriccancerbypropensityscorematchingaretrospectivecomparativestudy AT tanfei surgicalandoncologicalefficacyoflaparoscopicassistedtotalgastrectomyversusopentotalgastrectomyforgastriccancerbypropensityscorematchingaretrospectivecomparativestudy AT xukai surgicalandoncologicalefficacyoflaparoscopicassistedtotalgastrectomyversusopentotalgastrectomyforgastriccancerbypropensityscorematchingaretrospectivecomparativestudy AT zhangnan surgicalandoncologicalefficacyoflaparoscopicassistedtotalgastrectomyversusopentotalgastrectomyforgastriccancerbypropensityscorematchingaretrospectivecomparativestudy AT yaozhendan surgicalandoncologicalefficacyoflaparoscopicassistedtotalgastrectomyversusopentotalgastrectomyforgastriccancerbypropensityscorematchingaretrospectivecomparativestudy AT yanghong surgicalandoncologicalefficacyoflaparoscopicassistedtotalgastrectomyversusopentotalgastrectomyforgastriccancerbypropensityscorematchingaretrospectivecomparativestudy AT zhangchenghai surgicalandoncologicalefficacyoflaparoscopicassistedtotalgastrectomyversusopentotalgastrectomyforgastriccancerbypropensityscorematchingaretrospectivecomparativestudy AT xingjiadi surgicalandoncologicalefficacyoflaparoscopicassistedtotalgastrectomyversusopentotalgastrectomyforgastriccancerbypropensityscorematchingaretrospectivecomparativestudy AT wangzaozao surgicalandoncologicalefficacyoflaparoscopicassistedtotalgastrectomyversusopentotalgastrectomyforgastriccancerbypropensityscorematchingaretrospectivecomparativestudy AT cuiming surgicalandoncologicalefficacyoflaparoscopicassistedtotalgastrectomyversusopentotalgastrectomyforgastriccancerbypropensityscorematchingaretrospectivecomparativestudy AT suxiangqian surgicalandoncologicalefficacyoflaparoscopicassistedtotalgastrectomyversusopentotalgastrectomyforgastriccancerbypropensityscorematchingaretrospectivecomparativestudy |