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GLP-1 receptor signaling in the laterodorsal tegmental nucleus attenuates cocaine seeking by activating GABAergic circuits that project to the VTA

An emerging preclinical literature suggests that targeting central glucagon-like peptide-1 receptors (GLP-1Rs) may represent a novel approach to treating cocaine use disorder. However, the exact neural circuits and cell types that mediate the suppressive effects of GLP-1R agonists on cocaine-seeking...

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Detalles Bibliográficos
Autores principales: Hernandez, Nicole S., Weir, Vanessa R., Ragnini, Kael, Merkel, Riley, Zhang, Yafang, Mace, Kyla, Rich, Matthew T., Pierce, R. Christopher, Schmidt, Heath D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164646/
https://www.ncbi.nlm.nih.gov/pubmed/33257815
http://dx.doi.org/10.1038/s41380-020-00957-3