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Relationship of Substance P with the Degree of Atopic Dermatitis Severity

INTRODUCTION: Atopic dermatitis (AD) is a chronic inflammatory skin disease that starts during childhood with a varied course. Itching or incessant itching in severe cases, sleep disturbance, and infection-prone skin are the typical symptoms of this disease. Substance P is postulated to have an impo...

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Autores principales: Paramita, Deryne Anggia, Nasution, Khairina, Lubis, Nova Zairina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164664/
https://www.ncbi.nlm.nih.gov/pubmed/34079320
http://dx.doi.org/10.2147/CCID.S306557
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author Paramita, Deryne Anggia
Nasution, Khairina
Lubis, Nova Zairina
author_facet Paramita, Deryne Anggia
Nasution, Khairina
Lubis, Nova Zairina
author_sort Paramita, Deryne Anggia
collection PubMed
description INTRODUCTION: Atopic dermatitis (AD) is a chronic inflammatory skin disease that starts during childhood with a varied course. Itching or incessant itching in severe cases, sleep disturbance, and infection-prone skin are the typical symptoms of this disease. Substance P is postulated to have an important role in AD. Increasing levels of substance P in AD induce the release of IFN-γ, IL-4, tumor necrosis factor-α (TNF-α), and IL-10 from peripheral blood mononuclear leukocytes, inducing an itching response. METHODS: This study is a cross-sectional study that aims to analyze the relationship between serum substance P levels and AD severity in children using Score of AD (SCORAD), and to determine the mean serum substance P levels and severity of AD in patients with AD. This study also aims to find out the correlation of substance P levels with the SCORAD values. RESULTS: Forty-six children (29 males; 17 females) with a mean age of 10.35 years (standard deviation (SD) = 4.01) were diagnosed with AD. The SCORAD index assessment was conducted to analyze AD (mean value, 23.15; SD = 9.42), and mild AD obtained the highest degree. The level of substance P was also examined (mean value, 300.88; SD = 127.55). DISCUSSION: This study did not find a significant relationship between substance P levels and AD severity (p-value = 0.880), and there was no significant correlation between substance P levels and SCORAD values (p-value = 0.233; r = −0.179). The limitations of this study include a small number of cases, no control group, and we only found two cases of severe AD. To generalize the results, further studies with wide range population and AD severity might be done in the future.
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spelling pubmed-81646642021-06-01 Relationship of Substance P with the Degree of Atopic Dermatitis Severity Paramita, Deryne Anggia Nasution, Khairina Lubis, Nova Zairina Clin Cosmet Investig Dermatol Original Research INTRODUCTION: Atopic dermatitis (AD) is a chronic inflammatory skin disease that starts during childhood with a varied course. Itching or incessant itching in severe cases, sleep disturbance, and infection-prone skin are the typical symptoms of this disease. Substance P is postulated to have an important role in AD. Increasing levels of substance P in AD induce the release of IFN-γ, IL-4, tumor necrosis factor-α (TNF-α), and IL-10 from peripheral blood mononuclear leukocytes, inducing an itching response. METHODS: This study is a cross-sectional study that aims to analyze the relationship between serum substance P levels and AD severity in children using Score of AD (SCORAD), and to determine the mean serum substance P levels and severity of AD in patients with AD. This study also aims to find out the correlation of substance P levels with the SCORAD values. RESULTS: Forty-six children (29 males; 17 females) with a mean age of 10.35 years (standard deviation (SD) = 4.01) were diagnosed with AD. The SCORAD index assessment was conducted to analyze AD (mean value, 23.15; SD = 9.42), and mild AD obtained the highest degree. The level of substance P was also examined (mean value, 300.88; SD = 127.55). DISCUSSION: This study did not find a significant relationship between substance P levels and AD severity (p-value = 0.880), and there was no significant correlation between substance P levels and SCORAD values (p-value = 0.233; r = −0.179). The limitations of this study include a small number of cases, no control group, and we only found two cases of severe AD. To generalize the results, further studies with wide range population and AD severity might be done in the future. Dove 2021-05-25 /pmc/articles/PMC8164664/ /pubmed/34079320 http://dx.doi.org/10.2147/CCID.S306557 Text en © 2021 Paramita et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Paramita, Deryne Anggia
Nasution, Khairina
Lubis, Nova Zairina
Relationship of Substance P with the Degree of Atopic Dermatitis Severity
title Relationship of Substance P with the Degree of Atopic Dermatitis Severity
title_full Relationship of Substance P with the Degree of Atopic Dermatitis Severity
title_fullStr Relationship of Substance P with the Degree of Atopic Dermatitis Severity
title_full_unstemmed Relationship of Substance P with the Degree of Atopic Dermatitis Severity
title_short Relationship of Substance P with the Degree of Atopic Dermatitis Severity
title_sort relationship of substance p with the degree of atopic dermatitis severity
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164664/
https://www.ncbi.nlm.nih.gov/pubmed/34079320
http://dx.doi.org/10.2147/CCID.S306557
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